Page 180 - 2023 SMOG Digital

TRANEXAMIC ACID B Lactation: Yes(Caution) Trade Name: Cyklokapron/Lysteda
Class / Mechanism of Action
Antifibrinolytic Agent, Hemostatic Agent
Displaces plasminogen from fibrin resulting in inhibition of fibrinolysis and inhibits the proteolytic activity of
plasmin
Indications:
• Trauma-associated hemorrhage: Casualty likely needing blood transfusion (hemorrhagic shock,
elevated lactate, one or more major amputations, penetrating torso trauma, or evidence of severe
bleeding)
• Post-Operative Hemorrhage by dissection, enteric staples or suspected internal bleeding
• Signs or symptoms of significant TBI or altered mental status associated with blast or blunt trauma
• Postpartum Hemorrhage (continued bleeding despite Oxytocin and fundal massage)
Contraindications
• TXA is contraindicated in trauma if dose is not given within first 3 hours following Traumatic
event (Ideal dosing time-frame is within 1 hour of trauma)
• Hypersensitivity to tranexamic
• Subarachnoid hemorrhage
• Thromboembolic disease (Cerebral Thrombosis, DVT, PE)
Adverse Reactions / Precautions
• Disseminated intravascular coagulation (DIC): Use with extreme caution in patients with DIC requiring
antifibrinolytic therapy; patients should be under strict supervision of a physician experienced in
treating this disorder. TXA should be used in Pt.'s with trauma related DIC however.
• Thrombosis (especially when given after 3hr from injury)
• Seizure
Dose and Administration: ADULT PEDIATRIC Always Reference BROSELOW Tape
Trauma-associated hemorrhage (unlabeled Trauma-associated hemorrhage (unlabeled
use): use):
IV: IV:
• Initial Dose: 2g TXA in 100cc NS or LR ASAP • Initial Dose: 15mg/kg via IV/IO Bolus (goal
via IV/IO Bolus, or 2g IV/IO push (1g over 1min within 1 minute),
per push) but NOT later than 3 hours after
injury.
• If patient received 1g of TXA prior and
<3hr from time of injury: 1g TXA IV/IO push
over 1 minute or mixed in 100cc NS or LR
Bolus. If >3hr from time of injury: DO NOT
administer TXA.
Suspected Post-Operative Hemorrhage by
dissection, enteric staples or suspected
internal bleeding:
• Initial Dose: 2g of TXA in 100cc NS or LR
ASAP via IV/IO Bolus or 2g IV/IO push (1g over
1 minute push) but NOT later than 3 hours after
start of suspected hemorrhage.

180