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VASOPRESSIN C Lactation?(Caution) Trade Name: Vasostrict
Class / Mechanism of Action
Antidiuretic Hormone Analog-Vasopressor
Vasopressin, at therapeutic doses used for vasodilatory shock, stimulates the AVPR1a (or V1) receptor
and increases systemic vascular resistance and mean arterial blood pressure; in response to these
effects, a decrease in heart rate and cardiac output may be seen.
Onset of action IV: Rapid with peak effect occurring within 15 minutes of initiation of continuous IV
infusion. Duration: Within 20 minutes after IV infusion terminated.
Indications
Labeled Indications: Treatment of hypotension, vascular failure in shock
Contraindications
• Hypersensitivity to Vasopressin or any component of the formulation
• Use with caution in patients with asthma, cardiovascular disease, renal disease, or a history of
seizure disorder
Adverse Reactions / Precautions
• No applicable use in hemorrhagic shock unless fluid replacement therapy maximized!
Maximize use of Blood products / Crystalloids before considering use in hemorrhagic shock.
• Assure adequate circulatory volume to minimize need for vasoconstrictors. Monitor BP closely, avoid
hypertension and adjust infusion rate as needed.
• Vesicant: Avoid extravasation, will cause tissue damage/necrosis, ensure proper needle placement
• Cardiac arrhythmias are possible, monitor with 12 lead EKG
Dose and Administration: ADULT PEDIATRIC Always Reference BROSELOW Tape
Hypotension / Shock: Hypotension / Shock:
Vasopressors should be used if patient is hypotensive Limited data available; efficacy results have
after fluid resuscitation to maintain mean arterial varied.
pressure (MAP) ≥65mmHg.
IV Infusion:
Use in addition to norepinephrine for raising MAP to • 0.17-8 miliunits/kg/min (0.01-0.48units/kg/
target or to decrease norepinephrine dosage. hr)
Titrate to lowest effective dose.
IV Infusion:
4 Unit bolus IV/IO followed by 0.04 U/min infusion to
maintain MAP>65mmHg

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