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SUCCINYLCHOLINE Lactation?(Caution) Trade Name: Anectine
Class / Mechanism of Action
Depolarizing Neuromuscular Blocking Agent (Paralytic)
Acts like acetylcholine, produces myoneural depolarization causing sustained flaccid skeletal muscle
paralysis. Onset of action IV: 30-60 seconds, Duration 5-9 minutes with single dose
Indications
Labeled Indications: Rapid Sequence Intubation and routine endotracheal intubation
Contraindications
• Hypersensitivity to succinylcholine or any component of the formulation
• Acute phase of injury following major burns, multiple trauma (greater than 5 days after injury)
• Myopathies associated with elevated serum creatine phosphokinase and myasthenia gravis
• DO NOT USE IN PATIENTS WITH BURNS, CRUSH INJURIES, OR HYPERKALEMIA
• Re-Dosing is not advised due to increased risk of Hyperkalemia
• Neuromuscular disease (Muscular dystrophy, Spinal Muscular Atrophy, etc.)
Adverse Reactions / Precautions
• May cause Bradycardia, Malignant hyperthermia, and increased intraocular pressure
• Severe hyperkalemia can develop in cases of chronic abdominal infection, burn injury, children with
skeletal muscle myopathy, subarachnoid hemorrhage, or conditions which cause degeneration of the
nervous system commonly greater than 5 days old. Potassium increase of 0.5mEq/L is expected with
use.
• Provides NO analgesia or sedation!
o Must provide appropriate sedation and analgesia prior to paralytic use and throughout
maintenance.
Dose and Administration: ADULT PEDIATRIC Always Reference BROSELOW Tape
RSI/ Neuromuscular blockade: RSII / Neuromuscular blockade:
IV: IV:
• 1-1.5mg/kg • <10kg:
o Initial: 1.5-2mg/kg/dose
Note: Pretreatment with 10% dosage of non- • >10kg:
depolarizing agents prior to neuromuscular-
blockade with Succinylcholine is NO LONGER o Initial: 1-1.5mg/kg/dose
ADVISED
Note: Pretreatment with 10% dosage of non-
depolarizing agents prior to neuromuscular-
blockade with Succinylcholine is NO LONGER
ADVISED

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