Page 174 - 2023 SMOG Digital

PROPOFOL B Lactation Yes(Not Recommended) Trade Name: Diprivan
Class / Mechanism of Action
General Anesthetic
Lipophilic intravenous general anesthetic.
Onset of action IV bolus: 9-51 seconds (average 30 seconds), Duration is dose and rate dependent: 3-10
minutes, prolonged with continued doses
Indications
Labeled Indications: Induction of anesthesia in patients ≥3 years of age; maintenance of anesthesia in
patients >2 months of age; sedation in intubated, mechanically-ventilated ICU patients
Contraindications
• Hypersensitivity to propofol or any component of the formulation
• Allergy to eggs, egg products, soybeans, soy products, and peanuts.
Adverse Reactions / Precautions
• May cause Hypotension especially in hypovolemic patients or if bolus dosing is used.
o Hypotension may result in reduction of MAP exceeding 30%
 Head Injury patients or those with suspected / known increased intracranial pressure
are at increased risk of decreased cerebral perfusion pressure.
• Do not use in pre-hospital trauma environment or in transfer patients unless directed by medical
director or provided written orders by referring provider.
• No Analgesic properties. Must supplement with analgesic agents.
Dose and Administration: ADULT PEDIATRIC Always Reference BROSELOW Tape
Sedation/ RSI: Sedation/ RSI:
IV Push: IV Push:
• 1-2.5mg/kg q5-10min prn • 1-2.5mg/kg q5-10min prn
Maintenance of general anesthesia: Maintenance of general anesthesia,
IV Infusion: IV Infusion:
• 10-75mcg/kg/min via infusion pump or Dial-a- Healthy children 2 months to 16 years:
Drip. Titrate to minimum effective dose. (See • 125-300mcg/kg/min (or 7.5-18mg/kg/hr)
infusion chart next page)
o MAX DOSE: 100mcg/kg/min.
• Use of Dial-a-Drip tubing in the absence of an
infusion pump will increase accuracy of
infusion dosage.

Note: Wait 3-5 minutes between dosage changes
to clinically assess drug effects. Smaller doses are
required when used with opioids.

174