Page 169 - 2023 SMOG Digital

ONDANSETRON B Lactation?(Caution) Trade Name: Zofran
Class / Mechanism of Action
Antiemetic
Blocks serotonin, peripherally on vagus nerve terminals and centrally. Onset of action is 5-30min
dependent on route.
Indications
Labeled Indications: Prevention of postoperative nausea and vomiting
Unlabeled: Hyperemesis gravidarum (severe or refractory)
Contraindications
• Hypersensitivity to ondansetron or any component of the formulation
Adverse Reactions / Precautions
• Dose dependent QT interval prolongation occurs and IV doses >16mg are not recommended.
o In most patients, QT changes are not clinically relevant; however, if used with other
medications that prolong QT intervals (antiarrhythmics) or in those at risk for QT prolongation,
arrhythmia can occur. Torsades de points has been reported.
Dose and Administration: ADULT PEDIATRIC Always Reference BROSELOW Tape
Nausea and Vomiting (Children 1 month to 12
Nausea and Vomiting: years):
IV/IO/IM/PO IV:
• 4-8mg
• ≤40 kg: 0.1mg/kg as a single dose over 2-5min
Treatment of severe or refractory hyperemesis • >40 kg: 4mg as a single dose over 2-5min
gravidum (unlabeled use):
IV:
• 8mg administered over 15min q12hr

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