Page 165 - 2023 SMOG Digital

NIFEDIPINE Lactation Yes(Not Recommended) Trade Name: Procardia
Class / Mechanism of Action
Antianginal Agent, Calcium Channel Blocker
Inhibits movement of calcium ion across cell membranes of smooth muscle and myocardium resulting in
relaxation of coronary vascular smooth muscle and vasodilation as well as reduced peripheral vascular
resistance (reducing blood pressure).
Indications
Labeled Indications: Chronic stable or vasospastic angina
Unlabeled: Prevention and treatment of high altitude pulmonary edema
Contraindications
• Hypersensitivity to nifedipine or any component of the formulation
• Cardiogenic Shock
• Acute MI
Adverse Reactions / Precautions
• Symptomatic hypotension:
• Bradycardia, nausea
Dose and Administration: ADULT PEDIATRIC Always Reference BROSELOW Tape
High altitude pulmonary edema (unlabeled use): High altitude pulmonary edema (Not FDA
PO: approved for use in children) (unlabeled use):
• 10mg q4-6hr PO:
• Immediate release: 0.5mg/kg/dose
Pulmonary hypertension (unlabeled use) (maximum: 20mg/dose) q8hr
PO:
• 30mg (Extended Release) twice daily; may Note: Treatment is needed only necessary if
increase cautiously to 120-240mg/day response to oxygen and/or descent is poor.

Note: Do not use for acute anginal episodes; may
precipitate myocardial infarction

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