Page 163 - 2023 SMOG Digital

MOXIFLOXACIN Lactation Yes Trade Name Avelox
Class / Mechanism of Action
Antibiotic (Fluoroquinolone)
Bactericidal - DNA gyrase inhibitor and topoisomerase IV inhibitor–which is an essential enzyme that
maintains the superhelical structure, replication, transcription, and repair of bacterial DNA.
Indications
Labeled Indications: Used for infection control prophylaxis for traumatic open injuries and surgical
prophylaxis.
Contraindications
• Hypersensitivity to cefazolin, other cephalosporin antibiotics, other beta-lactams, or any component of
the formulation
• May cause QT prolongation.
• Avoid use in known aortic aneurysm or dissection
Adverse Reactions / Precautions
• Superinfection – prolonged use may result in fungal or bacterial superinfection (including C.Difficile)
Dose and Administration: ADULT PEDIATRIC
Infection Control: Infection Control:
For PO tolerable patients
PO:
PO: Pediatrics:
Adults: <15yrs old:
• 400mg once daily 10mg/kg/day PO
o Max daily dose: 400mg/day
o Max daily dose: 400mg/day
15yrs old:
• 400 mg once daily
o Max daily dose: 400mg/day

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