Page 159 - 2023 SMOG Digital

METOCLOPRAMIDE B Trade Name: Reglan
Class / Mechanism of Action
Prokinetic Agent: Antiemetic, Upper GI Stimulant
Potent dopamine-receptor antagonist. At higher doses blocks serotonin receptor in chemoreceptor trigger
zones of CNS. Increases GI tract motility and gastric emptying. Onset of action 1-5 minutes via IV with a
duration of 1-2 hours.
Indications
Labeled Indications: Prevention of postoperative nausea and vomiting; Acid Reflux/Heartburn/GERD;
Migraine Headache
Contraindications
• Hypersensitivity to glucagon or any component of the formulation
• Insulinoma / Pheochromocytoma
Adverse Reactions / Precautions
• Hypersensitivity, History of tardive dyskinesia or dystonic reaction to Metoclopramide in the past, GI
Obstruction or Hemorrhage, and seizure disorder (epilepsy).
Dose and Administration: ADULT PEDIATRIC Always Reference BROSELOW Tape

5-10mg IV/IO slow push; repeat dose q20-30min Not recommended or approved for routine
prn for a max of 20mg. pediatric use

*Rapid IV push may cause intense feelings of
anxiety and restlessness*
Ideal administration to Prevent Agitation/Adverse
Effects: Dilute in a 50 or 100mL NS bag and
infuse over 10-15 minutes.

159