Page 156 - 2023 SMOG Digital

MAGNESIUM SULFATE Lactation Yes(Caution)
Class / Mechanism of Action
Anticonvulsant, Electrolyte Supplement
IV magnesium decreases acetylcholine in motor nerve terminals and slows rate of SA node impulse
formation and prolongs conduction time. Magnesium functions to facilitate the movement of calcium,
sodium, and potassium in and out of cells.
Indications
Labeled Indications:
• Prevention and treatment of seizures in pregnancies with severe pre-eclampsia or eclampsia
• Torsades de Pointes: Cardiac arrhythmias (VT/VF) cause by low serum magnesium
Contraindications
• Hypersensitivity any component of the formulation
• Myocardial damage and heart blocks
• Use for pre-eclampsia/eclampsia during 2 hour period before delivery
Adverse Reactions / Precautions
• Possible cardiovascular arrest, respiratory depression, and hypotension in large doses
• Hypomagnesaemia is often joined by hypokalemia and requires correction in order to normalize
potassium.
Dose and Administration: ADULT PEDIATRIC Always Reference BROSELOW Tape
Torsades de pointes or VF/pulseless VT
associated with torsades de pointes (unlabeled Torsades de pointes:
use): IV/IO:
IV/IO: • 25-50mg/kg/dose over several minutes
• 1-2g over 15 minutes o maximum single dose: 2000 mg
Wheezing in Respiratory Distress (3rd line drug): Respiratory Distress:
IV: IV:
• 2g over 20min • 25-75mg/kg over 30min (max 2g)
Seizure (Refractory to Benzodiazepines):
IV:
• 1-2g over 30 min
Magnesium Sulfate should be diluted
Eclampsia/pre-eclampsia, severe (unlabeled): into 50-100mL NS or D5W for all Adult
IV: and Pediatric infusions
• 4-6g over 15-20 minutes followed by 2g/hr
continuous infusion

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