Page 164 - 2023 SMOG Digital

NALOXONE Lactation ?(Caution) Trade Name: Narcan
Class / Mechanism of Action
Antidote, Opioid Antagonist
Competes and displaces opioids at opioid receptor sites, reversing narcotic effects.
Indications
Labeled Indications: Reversal of opioid drug effects, including respiratory depression
Contraindications
• Hypersensitivity to naloxone or any component of the formulation
Adverse Reactions / Precautions
• When correcting for respiratory depression in a postoperative (intubated patient), carefully titrate the
dose to reverse hypoventilation; do not fully awaken patient or reverse analgesic effect.
• Recurrence of respiratory depression is possible continue to watch for respiratory depression until
patient hand-off.
• May cause narcotic withdrawal effects
Dose and Administration: ADULT PEDIATRIC Always Reference BROSELOW Tape
Opioid overdose (with standard ACS protocols): Opioid overdose (with standard PALS protocols):
IV, IM, SubQ: IV, IM, SubQ:
• 0.4-2mg; may dose q2-3min prn • <5 years or ≤20kg (unlabeled dose): 0.1mg/kg/
dose (maximum dose: 2mg); repeat q2-3min
o If no response after 10mg total, look prn
for other cause of respiratory • ≥5years or >20kg: Adult Dosing
depression.
Following reversal, may need to Reversal of respiratory depression with
o
readminister after 20-60min. therapeutic opioid doses:
IV, IM, SubQ:
Reversal of respiratory depression with • 0.001-0.015mg/kg/dose prn
therapeutic opioid doses:
IV, IM, SubQ:
• 0.1-0.4mg titrated to adequate respiratory rate.
If not improved after 0.8mg total, look for other
cause of respiratory depression.

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