Page 176 - 2023 SMOG Digital

ROCURONIUM C Lactation?(Caution) Trade Name: Zemuron
Class / Mechanism of Action
Nondepolarizing Neuromuscular Blocking Agent (Paralytic)
Blocks acetylcholine from binding to motor neuron receptors inhibiting depolarization.
Onset of action IV: 1-2min, Duration: approximately 25-40min (increases with higher doses)
Indications
Labeled Indications: Rapid Sequence Intubation/Paralysis and routine endotracheal intubation,
facilitates mechanical ventilation in ICU patients
Contraindications
• Hypersensitivity (eg, anaphylaxis) to rocuronium, other neuromuscular-blocking agents, or any
component of the formulation
Adverse Reactions / Precautions
• Resistance may occur in burn patients (>30% of body) for period of 5-70 days after injury
• High potential for interactions: Numerous drugs either antagonize (eg, acetylcholinesterase inhibitors)
or potentiate (eg, calcium channel blockers, certain antimicrobials, inhalation anesthetics, lithium,
magnesium salts, procainamide, and quinidine) the effects of neuromuscular blockade; use with
caution in patients receiving these agents.
• Provides NO analgesia or sedation!
o Must provide appropriate sedation and analgesia prior to paralytic use and throughout
maintenance.
Dose and Administration: ADULT PEDIATRIC Always Reference BROSELOW Tape
RSI: RSI:
IV Push: IV:
• 1mg/kg • 1mg/kg
(Dosing ranges from 0.6-1.2mg/kg) (Dosing ranges from 0.6-1.2mg/kg.)
Note: In adult patients with morbid obesity (BMI
>40kg/m ), use dose of 1.2mg/kg using ideal Maintenance bolus dosing: (unlabeled and
2
body weight (IBW) unreferenced dose)
IV Push:
Maintenance dosing: (unlabeled and • 1mg/kg every 30-45min (Dosing ranges from
unreferenced dose) 0.6-1.2mg/kg.)
IV Push:
• 1mg/kg IV/IO q30-45min prn or 8-12mcg/kg/
min IV/IO
(Dosing ranges from 0.6-1.2mg/kg)

176