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VECURONIUM C Lactation?(Caution) Trade Name: Norcuron
Class / Mechanism of Action
Nondepolarizing Neuromuscular Blocking Agent (Paralytic)
Blocks acetylcholine from binding to motor neuron receptors inhibiting depolarization.
Onset of action IV: 1.5-3 minutes, Duration: approximately 30-60 minutes
Indications
Labeled Indications: Endotracheal intubation, facilitates mechanical ventilation in ICU patients
Contraindications
• Hypersensitivity to vecuronium or any component of the formulation
Adverse Reactions / Precautions
• Resistance may occur in burn patients (>30% of body) for period of 5-70 days after injury
• High potential for interactions: Numerous drugs either antagonize (eg, acetylcholinesterase inhibitors)
or potentiate (eg, calcium channel blockers, certain antimicrobials, inhalation anesthetics, lithium,
magnesium salts, procainamide, and quinidine) the effects of neuromuscular blockade; use with
caution in patients receiving these agents.
• Provides NO analgesia or sedation!
o Must provide appropriate sedation and analgesia prior to paralytic use and throughout
maintenance.
Dose and Administration: ADULT PEDIATRIC Always Reference BROSELOW Tape
RSI) and maintenance of paralysis: RSI and maintenance of paralysis::
IV Push: IV Push:
• Induction: 0.1mg/kg • Induction: 0.1-0.15mg/kg
Dose range (0.8-0.15mg/kg) • Intermittent bolus dosing: 0.1mg/kg
• Maintenance: 0.1mg/kg q30-60min prn q30-60min prn
Dose range (0.8-0.15mg/kg) IV Continuous infusion:
• 1-2.5mcg/kg/min
IV Continuous infusion:
• 1 mcg/kg/min and titrate to 2:4 train of four
(TOF) if stimulation devise is available.
Note: Paralytic use and management: If available,
utilize the train of four stimulation device with either
the temple or radial/ulnar nerve placement.
Maintain paralysis at a level of 2/4 twitches with
TOF stimulation.
Note: Vecuronium is only recommended for use in
RSI in the absence of available Succinylcholine or
Rocuronium, as they are the preferred induction
agents.

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