Page 142 - 2023 SMOG Digital

FUROSEMIDE Lactation Yes (Caution) Trade Name: Lasix
Class / Mechanism of Action
Antihypertensive; Loop Diuretic
Inhibits reabsorption of sodium and chloride in the kidney, causing increased loss of water, sodium,
chloride, magnesium, and calcium within urine. When given IV it also causes rapid venous dilation.
Symptomatic improvement of acute pulmonary edema approximately 15-20 minutes
Indications
Labeled Indications: Management of edema associated with heart failure and hepatic or renal disease;
• Management of edema associated with heart failure and hepatic or renal disease; acute pulmonary
edema
• Hypertension (alone or in combination with other antihypertensives)
Contraindications
• Hypersensitivity to furosemide or any component of the formulation
• Anuria (No pre-hospital utility in hypovolemic shock)
Adverse Reactions / Precautions
• Can cause profound diuresis with resulting shock and electrolyte depletion. Monitor closely
o May cause: Hypovolemia, Hypotension, hyponatremia, hypokalemia
• May potentiate effect of additional antihypertensives
Dose and Administration: ADULT PEDIATRIC Always Reference BROSELOW Tape
Acute pulmonary edema:
IV Edema, heart failure: Infants and Children
• 40mg over 1-2min. If response not adequate IV, IM:
within 1hr, may increase dose to 80mg • Initial: 1mg/kg/dose; if response not adequate,
may increase dose in increments of 1mg/kg/
dose and administer not sooner than 2 hours
Edema, heart failure: after previous dose, until a satisfactory
IV, IM: response is achieved; may administer
• Initial: 20-40mg/dose; if response is not maintenance dose at intervals of q6-12hr;
adequate, may repeat the same dose or maximum dose: 6mg/kg/dose.
increase dose in increments of 20mg/dose and
administer 1-2 hours after previous dose
(maximum dose: 200mg/dose).
Continuous IV Infusion:
• Initial: IV bolus dose 20-40mg over 1-2
minutes, followed by continuous IV infusion
doses of 10-40mg/hr. If urine output is <1
mL/kg/hr, double as necessary to a
maximum of 80-160mg/hr.

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