Page 144 - 2023 SMOG Digital

HEPARIN Lactation No Trade Name:
Class / Mechanism of Action
Anticoagulant
Inactivates thrombin and activated coagulation factors (IX, X, XI, XII, and plasmin) and prevents
conversion of fibrinogen to fibrin.
Indications
Labeled Indications: Treatment of thromboembolic disorders
Unlabeled: ST elevation MI (STEMI) as an adjunct to thrombolysis; unstable angina/non-STEMI
Contraindications
• Hypersensitivity to heparin or any component of the formulation
• Active Bleeding (Trauma Patient)
Adverse Reactions / Precautions
• Continuously monitor for bleeding: Stop immediately if any bleeding occurs
• Urticarial reactions and anaphylaxis can occur
Dose and Administration: ADULT PEDIATRIC Always Reference BROSELOW Tape
Acute coronary syndromes: STEMI/Unstable Treatment of venous thromboembolism:
Angina as an adjunct to fibrinolysis (full-dose IV: (unlabeled dosing)
alteplase: >1 year
IV: • DVT/PE: 75units/kg IV push followed by
• Initial bolus of 60units/kg (MAX: 4000units) continuous infusion of 20units/kg/hr
o Maintenance: 12units/kg/hr (MAX:
1000units/hr) as continuous
infusion.
Treatment of venous thromboembolism:
IV: (unlabeled dosing)
• DVT/PE: 80units/kg (or alternatively 5000
units) IV push followed by continuous infusion
of 18units/kg/hr
Note: Heparin is ONLY for use only under written
direction of referring provider or direct consultation
with medical director.

144