Page 126 - 2023 SMOG Digital

DEXAMETHASONE Lactation ?(Not Recommended) Trade Name: Decadron
Class / Mechanism of Action
Systemic Corticosteroid
Anti-inflammatory, Immunosuppressant Onset of action, IV: Prompt; Duration IV: 72 hours
Indications
Labeled Indications:
• Anti-inflammatory or immunosuppressant in treatment of a variety of diseases: allergic, dermatologic,
endocrine, hematologic, inflammatory, neoplastic, renal, respiratory, rheumatic, and autoimmune
• Management if cerebral edema
Unlabeled:
• Treatment of acute mountain sickness (AMS) and high altitude cerebral edema.
Contraindications
• Hypersensitivity to dexamethasone or any component of the formulation
• Systemic fungal infection, cerebral malaria
Adverse Reactions / Precautions
• Not for use in treatment of head injury; increased mortality has occurred in head injury patients
treated with high dose IV methylprednisolone. Corticosteroids should not be used in head injuries.
Dose and Administration: ADULT PEDIATRIC Always Reference BROSELOW Tape
Acute mountain sickness (AMS)/high altitude Acute mountain sickness (AMS)/high altitude
cerebral edema (HACE) (unlabeled use): cerebral edema (HACE) (unlabeled use):
PO, IM, IV: PO, IM, IV:
• AMS: 4mg q6hr • 0.15mg/kg/dose q6hr
• HACE: 8mg as a single dose; followed o consider use in high altitude pulmonary
with: 4mg q6hr until symptoms resolve edema because of associated HACE
with pulmonary edema

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