Page 130 - 2023 SMOG Digital

DIPHENHYDRAMINE Lactation Yes (Unsafe) Trade Name: Benadryl
Class / Mechanism of Action
Histamine H1 Antagonist;
Competes with histamine for H1-receptor sites within the gastrointestinal tract, blood vessels, and
respiratory tract; Also produces anticholinergic and sedative effects
Indications
Labeled Indications:
• Anaphylaxis and allergy disorders
• Motion Sickness
• Antitussive
Contraindications
• Hypersensitivity to diphenhydramine or any component of the formulation
• Acute Asthma
• Use on Neonates, premature infants, Nursing mothers
Adverse Reactions / Precautions
• Normally causes sedation, but may cause paradoxical excitation in children
• May have increased sedative effects when used with other sedatives or alcohol
• May cause hypotension (use with caution in patient with cardiovascular disease)
• Dry mouth
Dose and Administration: ADULT PEDIATRIC Always Reference BROSELOW Tape
Anaphylaxis/Allergic Reactions and Motion Anaphylaxis/Allergic Reactions and Motion
Sickness: Sickness:
Oral: Oral, IM, IV:
• 25-50mg q6-8hr • 1mg/kg q6hr
IV Push:
• 50mg once, prepare to administer epinephrine
Max Doses:
Acute Hemolytic reaction (rapid onset of itching, 2 to <6 years:
chills, flushing, nausea/vomiting, coughing, • 6.25mg every 4-6hr; max of 37.5mg/day
wheezing, laryngeal edema, dyspnea, hypotension
hemoglobinuria, rise in venous pressure, distended 6 to <12 years:
neck veins, crackles in lung bases): • 12.5-25mg every 4-6hr; max of 150mg/day
IV:
• 50mg once, after administration of epinephrine >12 years:
0.5mL in lateral thigh • See Adult dosing

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