Page 125 - 2023 SMOG Digital

CEFAZOLIN Lactation Yes Trade Name: Ancef
Class / Mechanism of Action
st
Antibiotic (Cephalosporin 1 Gen)
Bactericidal - Inhibits bacterial cell wall synthesis by binding to one or more of penicillin-binding proteins
which inhibits cell wall biosynthesis, causing bacteria to eventually lyse.
Indications
Labeled Indications: Used for infection control prophylaxis for traumatic open injuries and surgical
prophylaxis.
Contraindications
• Hypersensitivity to cefazolin, other cephalosporin antibiotics, other beta-lactams, or any component of
the formulation
• Some cross reactions occur in those with penicillin allergies. Use with caution.
Adverse Reactions / Precautions
• Superinfection – prolonged use may result in fungal or bacterial superinfection (including C.Difficile)
• Increased INR (bleeding risk) – especially in nutritionally-deficient, hepatic/renal disease, prolonged
treatment
Dose and Administration: ADULT PEDIATRIC
Infection Control: Infection Control:
Routine dosing may be based on body mass:
1g if weight <80kg IV:
2g if weight 81-160kg (177-352lbs), Pediatrics:
3g if weight > 160kg (>352lbs) • 20-30mg/kg IV q6-8hr (maximum, 100mg/kg/
Max dose is 12g per day day)
o Max daily dose: 100mg/kg/day
War wounds (dirty wounds), 2g in 250 mL NS IV
over 5 min q8hr for 24 hours is adequate for most
dirty wounds of the head and nek, torso, and
extremities
IV:
Adults:
• 1-2g every 6-8hr
o Max daily dose: 12g/day

125