Page 131 - 2023 SMOG Digital

DOBUTAMINE B Lactation? (Caution) Trade Name: Dobutrex
Class / Mechanism of Action
Adrenergic Agonist
Positive Inotropic agent. Stimulates beta1 adrenergic receptors: Increases HR and contraction force
while sparing beta2 and alpha receptors. Onset IV: 1-2min
Indications
Labeled Indications: Short term management of cardiac decompensation.
Contraindications
• Hypersensitivity to dobutamine or sulfites (some contain sodium metabisulfate), or any component of
the formulation
• Idiopathic hypertrophic subaortic stenosis (IHSS)
Adverse Reactions / Precautions
st
• Always attempt to correct Hypovolemia 1 when using vasopressors and/or inotropes
o May be combined with Dopamine or Norepinephrine for hypotension not responding to
fluid administration
o No applicable use in hemorrhagic shock until fluid replacement therapy maximized!
• Increase in BP is common, but does have a rare incidence of causing hypotension
• Increases HR
• May exaggerate ventricular ectopy
Dose and Administration: ADULT PEDIATRIC Always Reference BROSELOW Tape
Cardiac Decompensation: Cardiac Decompensation:
IV: IV
Dobutamine may be combined with dopamine or • Refer to adult dose
norepinephrine for hypotension not responsive to
fluid therapy.
• 2-20mcg/kg/min, start low and titrate to
targeted MAP >60mmHg

• Preparation: Mix 250mg Dobutamine in
250mL D5W or NS for a concentration of
1000mcg/mL
Infusion Rates for Dobutamine at 1000mcg/mL
Desired Delivery Rate Infusion Rate
(mcg/kg/min) (mL/kg/hr)
2.5 0.15
5 0.3
7.5 0.45
10 0.6
12.5 0.75
15 0.9
20 1.2

131