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FIGURE 5 Mean arterial pressure plotted during the first 60 minutes Author Contributions
of fluid resuscitation. (A) Mean MAP was extracted every 30 seconds NJW and SAS conceived the study concept and obtained fund-
and plotted by group for the first 60 minutes of resuscitation. (B) The ing. XW, KR, CYH, and JCB conducted experiments and pro-
mean difference plotted. MAP was initially increased briefly with
bolus compared with infusion at the onset of fluid resuscitation, but vided critical input and revisions to the project. CA and AW
then decreased for the remainder of the first 60 minutes. Data in provided key data analysis and interpretation. NJW wrote the
panel A are plotted as means with fitted smoothed line graph. first draft, and all authors provided critical revision and read
and approved the final manuscript.

Financial Disclosure
The authors have indicated they have no personal financial
relationships relevant to this article to disclose.

Funding
This work was supported by U.S. Department of Defense Award
W81XWH-17-1-065, Defense Medical Research and Develop-
ment Program—Prolonged Field Care Research Award. Opin-
ions, interpretations, conclusions, and recommendations are
those of the author and are not necessarily endorsed by the
Dept. of Defense.

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