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■   Difficult analgesia or sedation needed is for patients in whom stan-  ■   Position the patient as comfortably as possible. Pad pressure points.
                dard analgesia does not achieve adequate pain control without sup-  ■   Provide anything that gives the patient comfort (e.g., water, food,
                pressing respiratory drive or causing hypotension, OR when mission   cigarette).
                requirements necessitate sedating a patient to gain control over their   ■   Under no circumstances should paralytics be used without analgesia/
                actions to achieve patient safety, quietness, or necessary positioning.  sedation
              ■   Protected airway with mechanical ventilation is for patients who   *Link to Analgesia and Sedation Management in Prolonged Field Care,
                have a protected airway and are receiving mechanical ventilatory   11 May 2017 CPG 15
                support or are receiving full respiratory support via assisted venti-  *Link to Pain, Anxiety and Delirium, 26 April 2021 CPG 16
                lation (i.e., bag valve).
              ■   Shock present is for patients who have hypotension, active hemor-  Antibiotics, Sepsis, and Other Drugs – SMSGT Brit Adams
                rhage, and/or tachycardia.
              Step 2 Read down the column to the row representing your available   Background
                                                                 Complete Basic TCCC Management Plan for Antibiotics then:
              resources and training.
                                                                 ■   Antibiotics should be given immediately after injury or as soon as
              Step 3. Provide analgesia/sedation medication accordingly.  possible after the management of MARCH and Pain Management
                                                                   and appropriately documented (medication administered, dose,
              Step 4. Consider using the Richmond Agitation-Sedation Scale (RASS)   route and time).
              score (Appendix E) as a method to trend the patient’s sedation level.
                                                                                                          ®
                                                                 ■   Confirm that initial TCCC dose of moxifloxacin (Avelox ) or Erta-
              Special Considerations                               penem (Invanz ) have already been given for any penetrating trauma.
                                                                             ®
              Patient Monitoring During Sedation                   If available, administer tetanus toxoid IM as soon as possible.
              Patients receiving analgesia and sedation require close monitoring for
              life-threatening side-effects of medications.      Antibiotics should be given daily for seven to 10 days, depending on
              ■   Minimum: Blood pressure cuff, stethoscope, pulse oximeter; doc-  the type of antibiotic given (see below tables for antibiotics). When
                ument vital signs trends.                        able/available, transition IV/IO antibiotics to PO as soon as possible
              ■   Better: Capnography in addition to minimum requirements  to conserve supplies and equipment (see Tables 11 and 12).
              ■   Best: Portable monitor providing continuous vital signs display   TABLE 11  TCCC Antibiotics
                and capnography; document vital signs trends frequently.
                                                                                  TCCC Antibiotics
              Analgesia and Sedation for Expectant Care          Moxifloxacin (Avelox )  Administer 400mg PO daily for 10 days
                                                                               ®
              (i.e., End-of-Life Care)                           Ertapenem (Invanz )  Administer 1g daily IV/IO/IM for 10 days
                                                                             ®
              An unfortunate reality of our profession, both military and medical,   IV/IO to PO transition  When transitioning from Ertapenem to
              is that we encounter clinical scenarios that will inevitably end in a pa-  Moxifloxacin, begin Moxifloxacin
              tient’s death. In these situations, it is a healthcare provider’s obligation   immediately after the final dose of Ertapenem
              to give palliative therapy to minimize the person’s suffering. In these   for antibiotic overlap
              circumstances, the use of opioid analgesics and sedative medications is
              therapeutic and indicated, even if these medications worsen a patient’s   Sepsis Management
              vital signs (i.e., cause respiratory depression and/or hypotension). If a   ■   Blunt or penetrating injuries may cause sepsis in untreated or un-
              patient is expectant:                                dertreated patients
              ■   Teleconsultation                               ■   Early recognition of impending sepsis and immediate treatment are
              ■   Prepare to:                                      imperative to improve changes of survival
                   o Give opioid until the patient’s pain is relieved. If the patient is   ■   Maintain a high degree of suspicion for signs of early and/or pro-
                  unable to communicate their pain, give opioid medication until   gressing sepsis while performing continuous triage
                  the respiratory rate is less than 20/min.      ■   Sepsis is defined as suspected or proven infection plus evidence of
                   o If the patient complains of feeling anxious (i.e., is worrying   end organ dysfunction.
                  about the future but not complaining of pain) or he cannot   ■   The National Early Warning Score (NEWS)17 is an aggregate scor-
                  express himself but is agitated despite having a respiratory rate   ing system indicating early physiologic derangements:
                  less than 20/min, give a benzodiazepine until the anxiety is re-    o For the purposes of this guideline, a NEWS score of >2 is used
                  lieved or the patient is sedated (i.e., is not feeling anxious or is   to increase the sensitivity for detection of and evaluation for
                  no longer agitated).                               sepsis.

              TABLE 12  Alternative Antibiotics (used if supplies of TCCC antibiotics are limited, or as directed by medical control)
                                                        Alternate Antibiotics
                                           Good                       Better                      Best
              Soft Tissue Injury  Cefalexin PO or Bactrim DS PO  Cefazolin IM/IV/IO     Moxifloxacin PO or Ertapenem IV/IO
                                  Topical: Bacitracin                                   Topical: Mupriocin
              Suspected MRSA      Topical: Mupirocin     Ertapenem IV/IO                Moxifloxacin PO or Ertapenem IV/IO
                                                                                        + Vancomycin
              Open Fx (I/II)      Beta-lactam Allergy: Clindamycin   Cefazolin IV/IO    Ertapenem IV/IO or Moxifloxacin PO
                                  IV/IO
              Open Fx (III) no    Beta-lactam Allergy: Clindamycin   Ceftriaxone IV/IO  Ertapenem IV/IO or Moxifloxacin PO
              contamination       IV/IO + Levofloxacin IV/IO
              Open Fx (III) soil or fecal   Beta-lactam Allergy: Levofloxacin   Ceftriaxone IV/IO + Metronidazole IV/IO  Ertapenem IV/IO or Moxifloxacin PO
              contamination       IV/IO + Metronidazole IV/IO
              Penetrating Head Injury                    Ceftriaxone IV/IO + Metronidazole IV/IO  Ertapenem IV/IO or Moxifloxacin PO
              Penetrating Chest Injury                                                  Ertapenem IV/IO or Moxifloxacin PO
              Penetrating Abdominal Injury               Ceftriaxone IV/IO + Metronidazole IV/IO  Ertapenem IV/IO or Moxifloxacin PO
              Burns (only when sepsis is                                                Ertapenem IV/IO or Moxifloxacin PO
              suspected)
              Eye Injuries        Erythromycin ointment/drops  Ciprofloxacin drops (or if penicillin allergy)  Moxifloxacin PO or Ertapenem IV/IO
              Dental Injuries     Pen-VK or Augmentin PO  Clindamycin PO (or IV/IO) or if penicillin allergy Moxifloxacin PO or Ertapenem IV/IO

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