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TABLE 9  Continued
                                       PCC Role-based Guidance for Head Injury/TBI Management
           TCCC -  Role 1a:
            CPP  •  Identification and local wound management of any open head wounds/skull fractures. Priorities should include hemorrhage control, removal of
                   gross contamination, and protection/coverage of any exposed dura or brain matter.
                 •  MACE2 examination per TCCC guideline.
                 •  Serial GCS exams (Appendix E.)
                 •  Identify signs of elevated or rising ICP per Appendix E.
                 •  Initiate immediate treatment for signs of elevated ICP including initial bolus of 3%
                 •  hypertonic saline (HTS) 250–500mL. Alterative: 23.4% sodium chloride.
                 •  Administer TXA as single 2gram IV or IO bolus (no second dose required).
                 •  Communicate evacuation requirements (need for TBI evaluation, neurosurgery).
                 •  Communicate re-supply requirements.
                 Role 1b:
                 •  Re-assess and re-apply MARCH interventions.
                 •  Administer antibiotics for any open head wounds or skull fracture. (See Antibiotics). Continue resuscitation until:
                      o Minimum: palpable radial pulse or improved mental status
                      o Better: SBP > 90mmHg
                      o Best: SBP between 100–110mmHg
                      o If SBP remains less than 100–110mmHg despite appropriate resuscitation and hemorrhage control, a vasopressor agent should be started if
                     available.
                      o norepinephrine continuous infusion 0.1–0.4mcg/kg/min
                      o vasopressin continuous infusion 0.01–0.04 units
                 *All use of pressers should be administered by role-based approved protocols or teleconsultation approval
                 •  Serial neurologic checks and identify signs of elevated or rising intracranial pressure (Appendix E); If noted, the following interventions are recom-
                   mended, if possible:
                      o HTS administration (intermittent bolus versus continuous infusion) per Appendix E. Alternative: 23.4% sodium chloride.
                      o Administer seizure prophylaxis (1G Levetiracetam), if available.
                      o Supplemental oxygen to maintain O  sats > 94%, ETCO  if intubated with goal of norocapnia with pCO  of 35–40.
                                                       2
                                                                                    2
                                           2
                      o Brief (less than 30 min) moderate hyperventilation to goal pCO /ETCO  20–30 may be performed for signs of impending/active herniation
                                                                2
                                                           2
                     (pupil becomes fixed and dilated).
                 **Note: Use hyperventilation only as a temporizing measure while additional ICP treatments are being administered or tactical evacuation is in
                 process.
                 •  Repeat primary and secondary survey for any abrupt decline in the GCS or change in pupil exam to rule out non-neurologic causes.
                 •  Minimize analgesia and sedation agents, if possible, to preserve ability to obtain neurologic exam, but medical and operational considerations
                   should take priority if deeper sedation or paralysis required.
                 •  Teleconsultation with trauma surgeon and/or neurosurgeon as available.
                 •  Upgrade evacuation priority and destination (facility with neurosurgical capabilities) for patients with initial mild TBI who deteriorates to moder-
                   ate/severe TBI category.
                 •  Repeat triage evaluation and identification of non-survivable condition (or associated injuries) based on injury types/severity and required vs avail-
                   able resources.
                 Role 1c:
                 •  Continue serial neurologic checks including GCS and pupil exam at least hourly.
                 •  Immediate seizure treatment with benzodiazepines, consider ketamine for refractory seizures.
                 •  Temperature management and aggressive fever control.
                 •  Teleconsultation with trauma surgeon and/or neurosurgeon as available.
                 •  Upgrade evacuation priority and destination (facility with neurosurgical capabilities) for patients with initial mild TBI who deteriorates to
                   moderate/severe TBI category.
                 See Appendix E for additional TBI resources.
                 *Link to Traumatic Brain Injury in Prolonged Field Care, 6 December 2017 CPG 14
               receive) analgesic medication at first, and unstable patients may   ■   Additionally, ketamine, opioids, and benzodiazepines given to-
               require other therapies or resuscitation before the administra-  gether have a synergistic effect: the effect of medications given
               tion of pain or sedation medications.              together is much greater than a single medication given alone
            ■   Sedation is used to relieve agitation or anxiety and, in some   (i.e., the effect is multiplied, not added, so go with less than what
               cases, induce amnesia. The most common causes of agitation   you might normally use if each were given alone).
               are untreated pain or other serious physiologic problems like   ■   Pain medications should be given when feasible after injury or as
               hypoxia, hypotension, or hypoglycemia. Sedation is used most   soon as possible after the management of MARCH and appro-
               commonly to ensure patient safety (e.g., when agitation is not   priately documented (medication administered, dose, route and
               controlled by analgesia and there is need for the patient to re-  time). Factors for delayed pain management (other than Combat
               main calm to avoid movement that might cause unintentional   Pill Pack) are need for individual to maintain a weapon/security
               tube, line, dressing, splint, or other device removal or to allow a   and inability to disarm the patient.
               procedure to be performed) or to obtain patient amnesia to an   ■   PCC requires a different treatment approach than TCCC. Go
               event (e.g., forming no memory of a painful procedure or during   slowly, use lower doses of medication, titrate to effect, and
               paralysis for ventilator management).              re-dose more frequently. This will provide more consistent
            ■   In a Role 1 (or PCC) setting, intravenous (IV) or interosseous   pain control and sedation. High doses may result in dramatic
               (IO) medication delivery is preferred over intramuscular (IM)   swings between over sedation with respiratory suppression
               therapies. The IV/IO route is more predictable in terms of   and hypotension alternating with agitation and emergence
               dose-response relationship.                        phenomenon.
            ■   Each patient responds differently to medications, particularly   Drips and Infusions
               with respect  to dose. Some individuals require substantially   For IV/IO drip medications:  Use normal saline  to mix medication
               more opioid, benzodiazepine, or ketamine; some require sig-  drips when possible, but other crystalloids (e.g., lactated Ringer’s,
               nificantly less. Once you have a “feel” for how much medica-  Plasmalyte, and so forth) may be used if normal saline is not available.
               tion a patient requires, you can be more comfortable giving it   DO NOT mix more than one medication in the same bag of crystal-
               to patient with a broad range of injuries.
            ■   Similar amounts during redosing. In general, a single medica-  loid. Mixing medications together, even for a relatively short time,
                                                             may cause changes to the chemical structure of one or both medica-
               tion will achieve its desired effect if enough is given; however,   tions and could lead to toxic compounds.
               the higher the dose, the more likely the side effects.


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