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the performance of others more effectively. They noted   where trying to understand a causal link among genes,
          that such models would depend on several developments   environments, and performance will necessarily be re-
          to lead to what we are calling P2, including advances in   fracted, like light through a prism, by multiple sources
          methods to collect large amounts of data on individu-  of variance across biological, psychological, and social
          als and trustworthy analytic methods that can provide   worlds. Understanding and incorporating these inter-
          valid, reliable, and actionable insights and conclusions.   actions to help optimize performance may be the ulti-
          Hence, it was with some irony, perhaps, that Blackhurst   mate goal of P2; in the meantime, just getting a  better
          and Stone,  only 5 years later, commented on the strik-  handle on which variables matter most could offer
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          ing comparison between how we measure platforms and   near-term advantage.
          how we measure warfighters. Their article juxtaposed
          the measurements taken on an airplane and those taken
          on the pilot: Compared with the more than 1,500 mea-  Moving Ahead: Figuring Out What Matters Most
          surements taken each second across multiple aircraft
          parameters to monitor a fifth-generation jet fighter, the   “The first principle is that you must not fool
          pilot has only one sensor: one to monitor and determine   yourself—and you are the easiest person to
          whether he/she is alive.                               fool.”
                                                                                        —Richard Feynman
          As part of an effort to redress this situation, Ford et al.
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          outlined a sense–assess–augment framework that might   Clearly, P2, as both a concept and an applied approach,
          be used to guide the application of HPO or human per-  is in its infancy, as are many of the technical and method-
          formance augmentation into systems engineering across   ological advances likely to enable it. Yet there are reasons
          the services. Similarly, Department of Defense (DoD)   to be optimistic about possibilities for, and potential pay-
          laboratories (e.g., Telemedicine & Advanced Technol-  offs from, collecting, analyzing, and integrating growing
          ogy Research Center, US Army Research Institute of En-  amounts of higher quality data to begin to tailor HPO ap-
          vironmental Medicine, Air Resources Laboratory and   proaches to optimize any given individual’s performance.
          Army Research Institute, US Special Operations Com-  P2, if realized effectively, could presumably contribute to
          mand, Air Force Research Laboratory, Naval Health   the effectiveness and well-being of all SOF and those who
          Research Center, Naval Medical Research Center, Con-  provide support to them. Furthermore, P2 is likely to
          sortium for Health and Military Performance, and De-  align well with at least some elements of the DoD’s plans
          fense Threat Reduction Agency) and other groups have   to maintain competitive military advantage through the
          begun to take strides toward enabling P2 by investing in   “Third Offset,” which is part of DoD’s plan to ensure
          research in relevant areas (e.g., telemedicine, wearable   our service members, and, in particular, SOF, remain the
          efforts, biomarkers, genomics, proteomics).        world’s finest fighting force.  Among other elements of
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                                                             the Third Offset, one is an increasingly clear realization
          Yet humans present perhaps unique challenges when   that the most effective organizations will be those that can
          compared with understanding and optimizing the per-  quickly adapt to evolving circumstances and challenges.
          formance of physical and materials systems, many of   A key factor in adaptability will be the extent to which
          which are reflected in the current state of P2. First,   humans and machines can most effectively work together,
          where fighter jets and other platforms are, in principle,   leveraging each other’s strengths and complementing each
          wholly understandable (they were designed and come   other’s relative weaknesses.  It is not difficult to see how
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          with blueprints), humans and their variability are the   a P2 approach could enable better and more-integrated
          products of simultaneous and dynamic interactions   human–machine interactions and systems by identifying
          among biological, psychological, physical, and social   and using, rather than ignoring or averaging, important
          worlds; our brains and bodies do not, as far as we can   individual performance differences.
          tell, come with blueprints beyond the tantalizing, but
          still frustratingly complex and incomplete, information   This, of course, begs the question of which individual
          being discovered in our genetic material. Further, as   differences are actually the most important for factor-
          we have illustrated in this article, our differences are   ing into HPO programs as well as human–machine
          influenced by variations in structure and function at   teaming. Clearly, some differences are likely to be more
          almost every level: from the composition of our gut   significant than others, and this significance may vary
          microbiomes shaped by environmental experiences and   across different conditions and in different contexts.
          exposures, to our injury histories, inflammatory pro-  Hence, which differences matter most, and when and
          files, and genetic predispositions, to even the dynamics   for whom, should almost certainly be an integral part
          and  characteristics  of  our  social  networks  and  envi-  of any P2 program. In turn, this raises the question of
          ronments. This complexity makes human individual   how individualized is “individual enough”? At what
          differences a wicked game of “Chutes and Ladders,”   point are there diminishing returns in P2, where the



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