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TABLE 1  Fresh Whole Blood Transfusion Packing List  the role 2 and 3 follow-up, reviewed all documentation and
               1.  Fresh Whole Blood Transfusion Packing List 26  edited the manuscript. All authors read and approved the final
               2.  FDA-approved blood collection bag (Fenwal [McKesson]    manuscript.
                 bag used)
               3.  Blood administration set (either Y type or straight line with   References
                 170- to 260-µm filter)                          1.  Beckett MA, Callum J, da Luz LT, et al. Fresh whole blood trans-
                                                                    fusion capability for Special Operations Forces. Can J Surg. 2015;
               4.  2 × clamps for bloodline (mosquito forceps used)  58(3 Suppl 3):S153–S156.
               5.  Normal saline (100mL bag used)                2.  Advanced Tactical Paramedic Protocols (ATP-P) Handbook.
               6.  Intravenous (IV) catheter × 2 (18-G used)        10th ed. St. Petersburg, FL: J Spec Oper Med; 2017.
               7.  Alcohol prep pads × 2                         3.  Fisher AD, Miles EA, Cap AP, et al. Tactical damage control re-
               8.  Eldon blood typing kit × 2                       suscitation. Mil Med. 2015;180(8):869–875.
                                                                 4.  Cannon WB. Nature and treatment of wound shock and allied
               9.  PRN adapter (needless saline lock)               conditions. JAMA. 1918;70:607–621.
              10.  550 cord (9.5 in)                             5.  Moore FD. Should blood be whole or in parts? N Engl J Med.
                 a.  Anaphylaxis medications                        1969;280:327–328.
                                                                 6.  Holcomb JB, Jenkins D, Rhee P, et al. Damage control resus-
                 b. Diphenhydramine intramuscular (IM)/IV           citation: directly addressing the early coagulopathy of trauma.
                 c.  Epinephrine 1:1000 IM/IV                       J Trauma. 2007;62(2):307–310.
                 d. Ranitidine IM/IV                             7.  Bjerkvig CK, Strandenes G, Eliassen HS, et al. “Blood failure”
                                                                    time to view blood as an organ: how oxygen debt contributes
              11.  Decadron                                         to blood failure and its implications for remote damage control
              12.  Tape                                             resuscitation. Transfusion. 2016;56 Suppl 2:S182–S189.
              13.  Op-Site/Tegaderm                              8.  Repine TB, Perkins JG, Kauvar DS, Blackborne L. The use of fresh
                                                                    whole blood in massive transfusion. J Trauma. 2006;60:S59–S69.
              14.  Constricting band                             9.  Spinella PC, Perkins JG, Grathwohl JG, et al. Warm fresh whole
              15.  18-gauge needle                                  blood is independently associated with improved survival for pa-
                                                                    tients with combat-related traumatic injuries. J Trauma. 2009;66:
                                                                    S69–S76.
              vital signs. With proper training and familiarization, the abil-  10.  Nessen SC, Eastridge BJ, Cronk D, et al. Fresh whole blood use
              ity to execute the WBB procedure rapidly and safely is prac-  by forward surgical teams in Afghanistan is associated with im-
              tical, especially when donors’ blood types are preidentified.   proved survival compared to component therapy without plate-
                                                                    lets. Transfusion. 2013; 53(Suppl 1):107S–113S.
              Transfusion of relatively small volumes of a warm, fresh whole   11.  Shackelford SA, Del Junco DJ, Powell-Dunford N, et al. Asso-
              blood product provides an optimal resuscitation intervention   ciation of prehospital blood product transfusion during medical
              to bleeding casualties and may bridge casualties to evacuation   evacuation of combat casualties in Afghanistan with acute and
              and damage control surgery. This is especially relevant in cases   30-day survival. JAMA. 2017;318(16):1581–1591.
              where hemorrhage control can be achieved with prehospital   12.  Cordova C, Cap A, Spinella P. Fresh whole blood transfusion for
              interventions.                                        a combat casualty in austere combat environment. J Spec Oper
                                                                    Med. 2014;14(1):9–12.
                                                                 13.  Malsby R, Frizzi J, Ray P, Raff J. Walking donor transfusion in
              Conclusion                                            a far forward environment. South Med J. 2005;98(8):809–810.
                                                                 14.  Cap AP, Gurney J, Spinella PC, et al. Damage control resuscitation.
              Uncontrolled hemorrhage prior to reaching damage control   Joint Trauma System Clinical Practice Guideline. 12 July 2019.
              surgical care contributes disproportionately to battlefield mor-  https://jts.amedd.army.mil/assets/docs/cpgs/Damage_Control
              tality. Resuscitation from hemorrhagic shock requires blood   _Resuscitation_12_Jul_2019_ID18.pdf. Accessed 1 Oct 2021.
              products, however there are significant logistic barriers to car-  15.  Weiskopf RB, Ness PM. Transfusion for remote damage control
                                                                    resuscitation. Transfusion. 2013;53(1):8–12.
              rying cold-stored blood products to the point of injury. The   16.  Medby C. Is there a place for crystalloids and colloids in remote
              WBB capability is a lightweight and rapid method to provide   damage control resuscitation? Shock. 2014;41:47–50.
              medics with FWB, enable early resuscitation, and improve   17.  Zielinski MD, Jenkins DH, Hughes JD, et al. Back to the future:
              survival from severe traumatic injury. This capability should   The renaissance of whole-blood transfusions for massively hem-
              be expanded to all military medics, and medic training must   orrhaging patients. Surgery. 2014;155(5);883–886.
              include WBB with goal-directed tactical damage control re-  18.  Taylor AL, Eastridge BJ. Advances in the use of whole blood in
                                                                    combat trauma resuscitation. Transfusion. 2016;56:15a–16a.
              suscitation. These skills should be considered standard for all   19.  Bassett A, Auten J, Lunceford N. Early, prehospital activation of
              combat medics across the Department of Defense (DoD)  the walking blood bank based on mechanism of injury improves
                                                                    time to fresh whole blood transfusion. J Spec Oper Med. 2016;
              Disclosures                                           16:5–918.
              The authors declare that they have no competing interests.  20.  Rush S. Podcast episode 29: Dr. Cap on fresh whole blood and
                                                                    resuscitation for PFC. 18 Sept 2018.  https://prolongedfieldcare
                                                                    .org/2017/09/28/podcast-episode-29-dr-cap-on-fresh-whole
              Disclaimer                                            -blood-and-resuscitation-for-pfc/. Accessed 1 Oct 2021.
              The opinions or assertions contained herein are the private   21.  Eastridge BJ, Mabry RL, Seguin P, et al. Death on the battlefield
              views of the authors and not to be construed as official or as   (2001–2011): implications for the future of combat casualty care.
              reflecting the views of the Defense Health Agency or the De-  J Trauma Acute Care Surg. 2012;73(6 Suppl 5):S431–S437.
              partment of Defense. Public affairs office and operational se-  22.  Malsby RF, Quesada J, Powell-Dunford N, et al.  Prehospital
              curity reviews were conducted by the Defense Health Agency.  blood product transfusion by U.S Army MEDEVAC during com-
                                                                    bat operations in Afghanistan: a process improvement initiative.
                                                                    Mil Med. 2013;178:785–791.
              Authorship Contributions                           23.  Donham BP, Barbee GA, Deaton TG, et al. Risk associated with
              MG and AF conducted the mission and collected the docu-  autologous fresh whole blood training. J Spec Oper Med. 2019;
              mentation. MG and VH drafted the manuscript. SS provided   19(3):24–25.


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