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Stratifying sites according to flow rate is useful when high-   There are substantial data that support using an IO line when
          volume resuscitation is required. As previously discussed,   peripheral IV access is not attainable for various reasons.
          sternal and humoral sites have distinct flow rate advantages.   However, in our opinion, there is no formal stratification to
          Consistent with Wolf’s law, iliac crest access would also have a   help determine preferential location for access placement. The
          theoretical advantage. Due to the iliac crest being non–weight   iliac crest has some unique advantages compared with other
          bearing, density and flow resistance are relatively low. This   sites, such as site availability, potentially better flow rate, ease
          suggests flow rates would be similar to sternal IO flow rates.   of insertion, and workspace utilization.
          More devoted studies would be required to confirm this. Cer-
          tainly, tibial access consistently lags regarding this metric.  Conclusion
                                                             This is the first report of a whole blood transfusion through an
          Anatomic differences among the possible sites are important to   iliac crest IO for hemorrhagic shock in a military prehospital
          consider. The iliac crest has a relatively wide medullary cavity   setting. Based on our experience, the possibility of needing to
          and is deep considering the trajectory of IO placement, mak-  care for triple and quadruple amputees, as well as the favor-
          ing this site relatively straightforward (Figure 1). Compara-  able anatomic attributes of the iliac crest, makes the iliac crest
          tively, the medullary cavity of the sternum is shallower when   IO an important contingency in polytrauma patients when ex-
          approached  perpendicular  to  the  cortex.  Lack  of  a  distinct   tremity and sternal access are not available.
          bony  prominence  and  the  spherical  surface  of  the  humeral
          head make identifying this site more difficult. Additionally,
          extremity IO sites could be difficult to access in an agitated   References
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