Page 91 - JSOM Winter 2021
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If CEUS is used in penetrating abdominal injuries caused by   prehospital, trauma, hemorrhagic shock, optimal timing, opti-
              gunshot or stabbing typical findings have to be considered.   mal dose, safe volume, incidence of venous thromboembolism
              Material and methods: We report a case of gunshot wound of   (VTE), IM bioavailability. Results: In total, 186 studies were
              the liver during military mission in Afghanistan and a case of   reviewed. The strength of the available data was variable, and
              stab wound by knife of the left kidney. FAST was done in liver   ranged from laboratory research, case reports, retrospective
              gunshot as first diagnostic imaging. CEUS was performed ad-  observational reviews, with few prospective studies. Cur-
              ditionally in the emergency room (ER) by CX 50 Philips ultra-  rent volume and concentrations of available formulations of
              sound system and ultrasound contrast agent (UCA, SonoVue,   TXA make it amenable to IM injection. Current best-practice
              Bracco, Italy). CT scanning was performed after stabilization   guidelines for large volume injection (i.e. 5cc) support IM ad-
              in ER. CEUS was repeated during and after each following   ministration in 4 locations in the adult human body. There is
              operation. The stab wound to the kidney was a finding by   now new data demonstrating complete bioavailability of IM
              CEUS in a stable patient (Logiq E9 ultrasoundsystem, General   TXA in both healthy subjects and those in hemorrhagic shock,
              Electrics; UCA, SonoVue, Bracco, Italy). Active bleeding was   with serum concentrations achieving antifibrinolysis in a clin-
              excluded simultaneously.                           ically meaningful time. Conclusion: The available data on the
                                                                 out-of-hospital use of TXA supports its use in hemorrhagic
              Results: The extension of the gunshot to the liver could not
              be estimated on first CEUS examination due to aerodermecta-  shock, with maximal efficacy seen when TXA given as soon
              sia and gas echo extended along the bullet track. Subsequent   as possible from the point of injury. Studies on IM TXA are
              CEUS after first operations revealed that the wound track echo   limited, but the available data supports complete bioavailabil-
              was unenhanced in majority. Follow-up CEUS effectively de-  ity of IM TXA with peak concentrations sufficient to achieve
              tected the wound tract, hematoma, and the liver area injured   antifibrinolysis and in operationally meaningful time frames.
              by the gunshot and could accurately reveal necrotic tissue in   Balancing the available data and risk:benefit ratio, IM TXA
              the injured area.                                  should be considered a viable treatment option for tactical and
                                                                 combat applications.
              CEUS of the stabbed left kidney revealed a triangular area
              without perfusion in the lower pole without extravasation   Psychological Effects of Terrorist Attacks on
              of UCA as sign of a probable active bleeding. A diagnostic   Emergency Responders and Possibilities for
              laparoscopy revealed abdominal hemorrhage. The subsequent   Faster Detection
              laparotomy located an injury of the renal capsule causing a   Ulrich Wesemann, Oliver Hochfeld, Carolyn Rose,
              retroperitoneal hematoma. CT scanning was done 4 days after   Gerd Willmund, Chris Röhrich
              the Operation to rule out an urinoma. Conclusions: Applica-  Introduction: The prevalence rate for PTSD in emergency
              tion of CEUS may provide important imaging for gunshot and   service personnel (ESP) after terrorist attacks ranges between
              stab wounds. But in gunshot injuries the diagnostic validity   1.3% and 16.5%, for anxiety disorders  between 0.7% and
              in the initial examination is reduced by gas echos along the   14%, and for major depression between 1.3% and 25.8%. This
              bullet track. In contrast the stab wound is a sharp deep cut   wide range is attributed to different intensities of the terrorist
              and therefore the ultrasound examination is not hindered by   attacks. The aim is to develop and validate a questionnaire to
              entrapped air. Thus CEUS is an interesting diagnostic tool in   reduce stigma and to optimize the detection rate of soldiers
              blunt and penetrating trauma of the abdomen and may be an   and ESP with deployment-related mental disorders by involv-
              appropriate tool in between FAST and CT or instead of CT in   ing their partners. Methods: The partners assessed the changes
              the initial ER phase and in follow-ups. CEUS may spare time   in the soldiers with mental disorders following deployment.
              in ER and facilitate decision-making in case of mass casualties   The answers were categorized through thematic analysis and
              and may spare transport capacity in military missions.
                                                                 then used to develop a questionnaire. The questionnaire asks
                                                                 to rate the changes in the partners (soldiers) on a five-point
              Intramuscular (IM) Tranexamic Acid (TXA) in        Likert scale. In a pre-test, N = 47 partners of soldiers who
              Tactical And Combat Settings: Data to Support      had been stationed abroad in the past 12 months completed
              IM TXA at the Point of Injury                      the questionnaire. Half of the soldiers were diagnosed with
              Erik N. Vu, MSM, CCP, MD, FRCPC                    a mission-related mental disorder (n = 24) and the other half
                                                                 (n = 23) were not. The presence/absence of mental disorders
              Introduction:  Uncontrolled hemorrhage remains a leading   was verified through a psychiatric interview.  Findings: Out
              cause of preventable death in tactical and combat settings.   of 33, the top 24 ranking items with a discriminatory power
              Recent attention on the use of TXA as an adjunct in the man-  >.5 were included in the final version of the questionnaire.
              agement of hemorrhagic shock has resulted in investigations   Cronbach’s alpha was.98. Preliminary cut-off values were cal-
              into alternate routes of delivery. Balancing tactical priorities,   culated by ROC analyses with a sensitivity and specificity of
              maintaining situational awareness and the time and skill re-  over 90% (AUC = .93). Conclusions: The main evaluation of
              quired to obtain vascular access while under duress, the ques-  the final test version is running now with a state and a trait
              tion was raised as to the potential role for IM administration   component. Cronbach’s alpha, a cut-off value as well as sen-
              of TXA in the out-of-hospital setting, as soon as possible from   sitivity and specificity are calculated. This approach actively
              the point of injury. A working group for the Committee for   addresses the greatest and most pressing problem currently
              Tactical Emergency Casualty Care was established to review   facing military psychology in the Bundeswehr. Nevertheless, it
              the available evidence on this subject. Methods: Embase  and   is only one tool in a complex system of measures.
                                                         ®
              Medline /PubMed  databases were searched by professional
                            ®
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              medical librarians from the College of Physicians and Sur-
              geons of British Columbia, Canada. These databases were se-  Keywords: mental health; military psychology; military person-
              quentially searched to assess for evidence on the use of TXA in   nel; emergency responders; stigma; partners; health services
              the following contexts, and/or using the following key words:   accessibility
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