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WH-09-1-0750, W81XWH-09-C-0160, W81XWH-11- 10. Moulton SL, Mulligan J, Grudic G, et al. Running on empty?
2-0091, W81XWH-11-2-0085, and W81XWH-12-2- The compensatory reserve index. J Trauma Acute Care Surg.
2013;75:1053–1059.
0112) and the US Army Small Business Innovative Re- 11. Tisherman S, Barie P, Bokhari F, et al. Clinical practice guide-
search Program (Grant W81XWH-13-C-0121). line: endpoints of resuscitation. J Trauma. 2004;577:898–912.
12. Convertino VA, Howard JT, Hinojosa-Laborde C, et al. In-
dividual-specific, beat-to-beat trending of significant human
Disclaimers blood loss: the compensatory reserve. Shock. 2015;44(Suppl
1):27–32.
The opinions or assertions contained herein are the pri- 13. Schlader ZJ, Gagnon D, Rivas E, et al. Fluid restriction during
vate views of the authors and are not to be construed as exercise in the heat reduces tolerance to progressive central
official or as reflecting the views of the Department of hypovolaemia. Exp Physiol. 2015;100:926–934.
the Army or the Department of Defense. This study was 14. Janak JC, Howard JT, Goei KA, et al. Predictors of the onset
conducted under a protocol reviewed and approved by of hemodynamic decompensation during progressive central
the US Army Medical Research and Materiel Command hypovolemia: comparison of the peripheral perfusion index,
pulse pressure variability, and compensatory reserve index.
Institutional Review Board and in accordance with the Shock. 2015;44:548-553.
approved protocol. 15. Tsatsaris V, Cabrol D, Carbonne B. Pharmacokinetics of to-
colytic agents. Clin Pharmacokinet. 2004;43:833–844.
16. Abella B, Edelson D, Kim S, et al. CPR quality improvement
Disclosures during in-hospital cardiac arrest using a real-time audiovisual
feedback system. Resuscitation. 2007;73:54–61.
Drs Grudic and Mulligan codeveloped the CRI model 17. Armed Forces Health Surveillance Center. Syncope, active
used in this study. Dr Moulton is a cofounder and and reserve components, U.S. Armed Forces, 1998–2012.
medical consultant to Flashback Technologies, Inc. Drs MSMR. 2013;20:5–9.
Stewart and Convertino and Ms Nawn have nothing to 18. Hinojosa-Laborde C, Shade RE, Muniz GW, et al. Validation
disclose. of lower body negative pressure as an experimental model of
hemorrhage. J Applied Physiol. 2014;116:406–415.
19. Muniz GW, Wampler DA, Manifold CA, et al. Promoting early
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Machine Learning and Hemodynamic Instability 13

