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WH-09-1-0750, W81XWH-09-C-0160, W81XWH-11-         10.  Moulton SL, Mulligan J, Grudic G, et al. Running on empty?
              2-0091, W81XWH-11-2-0085, and W81XWH-12-2-            The compensatory reserve index. J Trauma Acute Care Surg.
                                                                    2013;75:1053–1059.
              0112) and the US Army Small Business Innovative Re-  11.  Tisherman S, Barie P, Bokhari F, et al. Clinical practice guide-
              search Program (Grant W81XWH-13-C-0121).              line: endpoints of resuscitation. J Trauma. 2004;577:898–912.
                                                                 12.  Convertino VA, Howard JT, Hinojosa-Laborde C, et al. In-
                                                                    dividual-specific, beat-to-beat trending of significant human
              Disclaimers                                           blood loss: the compensatory reserve. Shock. 2015;44(Suppl
                                                                    1):27–32.
              The opinions or assertions contained herein are the pri-  13.  Schlader ZJ, Gagnon D, Rivas E, et al. Fluid restriction during
              vate views of the authors and are not to be construed as   exercise in the heat reduces tolerance to progressive central
              official or as reflecting the views of the Department of   hypovolaemia. Exp Physiol. 2015;100:926–934.
              the Army or the Department of Defense. This study was   14.  Janak JC, Howard JT, Goei KA, et al. Predictors of the onset
              conducted under a protocol reviewed and approved by   of hemodynamic decompensation during progressive central
              the US Army Medical Research and Materiel Command     hypovolemia: comparison of the peripheral perfusion index,
                                                                    pulse pressure variability, and compensatory reserve index.
              Institutional Review Board and in accordance with the   Shock. 2015;44:548-553.
              approved protocol.                                 15.  Tsatsaris V, Cabrol D, Carbonne B. Pharmacokinetics of to-
                                                                    colytic agents. Clin Pharmacokinet. 2004;43:833–844.
                                                                 16.  Abella B, Edelson D, Kim S, et al. CPR quality improvement
              Disclosures                                           during in-hospital cardiac arrest using a real-time audiovisual
                                                                    feedback system. Resuscitation. 2007;73:54–61.
              Drs Grudic and Mulligan codeveloped the CRI model   17.  Armed Forces Health Surveillance Center. Syncope, active
              used in this study. Dr Moulton is a cofounder and     and reserve components, U.S. Armed Forces, 1998–2012.
              medical consultant to Flashback Technologies, Inc. Drs   MSMR. 2013;20:5–9.
              Stewart and Convertino and Ms Nawn have nothing to   18.  Hinojosa-Laborde C, Shade RE, Muniz GW, et al. Validation
              disclose.                                             of lower body negative pressure as an experimental model of
                                                                    hemorrhage. J Applied Physiol. 2014;116:406–415.
                                                                 19.  Muniz GW, Wampler DA, Manifold CA, et al. Promoting early
              References                                            diagnosis of hemodynamic instability during simulated hem-
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              2.  Brasel KJ, Guse C, Gentilello LM, et al. Heart rate: is it truly a   Dr Stewart is with the University of Colorado School of
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              3.  King RW, Plewa MC, Buderer NM, et al. Shock index as a   Medicine, Department of Surgery, and the Children’s Hospital
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              4.  Convertino VA, Ryan KL, Rickards CA, et al. Physiological   Ms Nawn is with the US Army Institute of Surgical Research,
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              7.  Rhee P. Sabiston textbook of surgery. 19th ed. Oxford, UK:
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              9.  Convertino VA, Mulligan J, Grudic G, et al. Estimation of   Dr Convertino is with the US Army Institute of Surgical Re-
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