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be incorporated as biodefense countermeasures. Medical plan Sci Eng Med. https://nap.nationalacademies.org/catalog/25889/
ners and providers should consult their combatant command anassessmentofillnessinusgovernmentemployeesandtheir
and unitspecific doctrine and policies for additional guidance. familiesatoverseasembassies. Accessed 15 July 2022.
General information about the military smallpox program and 16. WHO. Seventy-Fourth World Health Assembly: Progress re-
ports. Report by the Director-General. 24 May 2021. https://
a comprehensive list of DoDspecific resources are available at www.who.int/about/governance/worldhealthassembly/seventy
www.health.mil/smallpox. fourthworldhealthassembly. Accessed 15 July 2022.
17. Rathish B, Pillay R, Wilson A, Pillay VV. Comprehensive review
“Those who cannot remember the past are condemned of bioterrorism. StatPearls. 7 April 2021. https://www.ncbi.nlm.
to repeat it” nih.gov/books/NBK570614/. Accessed 15 July 2022.
—George Santayana, 1905 18. Henderson DA, Arita I. The smallpox threat: a time to reconsider
global policy. Biosecurity and Bioterrorism. 2014;12(3):117–121.
19. CDC. Bioterrorism agents/diseases. https://emergency.cdc.gov/
Author Contributions agent/agentlistcategory.asp . Accessed 15 July 2022.
AS drafted the original manuscript. SJZ contributed additional 20. Breman J, Henderson D. Diagnosis and management of small
sections and references. All authors reviewed and approved pox. NEJM. 2002;346(17):1300–1908.
the final manuscript. 21. Rao A. Smallpox. 1st ed. Mumbai, India: Kothari Book Depot;
1972.
22. Rao A. Clinical Smallpox Classification and Frequency of Type of
Disclosure Variola Major.; 1972.
The authors have nothing to disclose. 23. US Army Medical Research Institute of Infectious Disease.
Quick bioagents: USAMRIID’s pocket reference guide to biolog
References ical select agents and toxins. 2021. https://usamriid.health.mil/
1. Atkinson W, Hamborsky J, McIntyre L. Smallpox. In: Epidemi- education/docs/Quick_Reference_Guide_BioQRG_2nd_Edition.
ology and Prevention of Vaccine-Preventable Diseases (The Pink pdf. Accessed 16 July 2022.
Book). 9th ed. Public Health Foundation; 2010. 24. Peterson BW, Damon IK, Pertowksi CA, et al. Clinical guid
2. Fenner F, Henderson D. Smallpox and Its Eradication. World ance for smallpox vaccine use in a postevent vaccination pro
Health Organization. 1988. https://apps.who.int/iris/bitstream/ gram. MMWR. 20 February 2015. https://www.cdc.gov/mmwr/
handle/10665/39485/9241561106.pdf?sequence=1&isAllowed preview/mmwrhtml/rr6402a1.htm. Accessed 16 July 2022.
=y. Accessed 15 July 2022. 25. MacIntyre CR, Das A, Chen X, et al. Evidence of longdistance
3. Henderson DA. The eradication of smallpox – an overview of the aerial convection of variola virus and implications for disease
past, present, and future. Vaccine. 2011;29(SUPPL. 4):D7–D9. control. Viruses. 2019;12(1).
4. Centers for Disease Control. History of smallpox. https://www 26. Milton DK. What was the primary mode of smallpox transmis
.cdc.gov/smallpox/history/history.html. Accessed 15 July 2022. sion? Implications for biodefense. Front Cell Infect Microbiol.
5. Alibek K. Smallpox: a disease and a weapon. Int J Inf Dis. 2012;2:150.
2004;8(SUPPL. 2):3–8. 27. Mayhew CJ, Hahon N. Assessment of aerosol mixtures of differ
6. Filsinger A. George Washington and the first mass military inocu ent viruses. Appl Microbiol. 1970;20(3):313–316.
lation (John W. Kluge Center, Library of Congress). Accessed Sep 28. Harper G. Airborne microorganisms – survival test with 4 vi
tember 15, 2021. https://www.loc.gov/rr/scitech/GW&smallpox ruses. J Hygiene. 1961;59:479–486.
inoculation.html 29. Costatino V, Kunasekaran M, Chughtai A, MacIntyre C. How
7. Alibek K, Tucker J. Biological weapons in the former Soviet valid are assumptions about reemerging smallpox? A systematic
Union: An interview with Dr. Kenneth Alibek. The Nonprolifera- review of parameters used in smallpox mathematical models. Mil
tion Review. 1999;Spring–Summer:1–10. Med. 2018;183(7–8):e200–e207.
8. Lane HC, la Montagne J, Fauci AS. Bioterrorism: A clear and 30. Military Health System. Smallpox (ACAM2000). https://health
present danger. Nature Medicine. 2001;7(12):1271–1273. .mil/MilitaryHealthTopics/HealthReadiness/Immunization
9. CDC. Smallpox. https://www.cdc.gov/smallpox/clinicians/index. Healthcare/VaccinePreventableDiseases/Smallpox
html. Accessed 15 July 2022. ACAM2000. Accessed 15 July 2022.
10. Deputy Secretary of Defense. Clarifying guidance for smallpox 31. Cono J, Casey C, Bell DM. Smallpox vaccination and adverse
and anthrax vaccine immunization programs. 12 November reactions. MMWR. 2003;52(RR04).
2015. https://health.mil/ReferenceCenter/Policies/2016/04/28/ 32. Grabenstein JD, Winkenwerder W. US military smallpox vaccina
ClarifyingGuidanceforSmallpoxandAnthraxVaccine tion program experience. JAMA. 2003;289(24).
ImmunizationPrograms. Accessed 15 July 2022. 33. Faix DJ, Gordon DM, Perry LN, et al. Prospective safety surveil
11. CDC, Morbidity and Mortality Weekly Report. Vaccinia (small lance study of ACAM2000 smallpox vaccine in deploying mili
pox) vaccine recommendations of the Advisory Committee on tary personnel. Vaccine. 2020;38(46):7323–7330.
Immunization Practices (ACIP), 2001. https://www.cdc.gov/ 34. Kennedy JS, Greenberg RN. IMVAMUNE : Modified vaccinia
®
mmwr/pdf/rr/rr5010.pdf. Accessed 15 July 2022. Ankara strain as an attenuated smallpox vaccine. Expert Review
12. Department of Defense. Smallpox response plan. 29 Septem of Vaccines. 2009;8(1):13–24.
ber 2002. https://biosecurity.fas.org/resource/documents/DoD_ 35. FDA. FDA approves first live, nonreplicating vaccine to prevent
Smallpox_Response_Plan.pdf. Accessed 15 July 2022. smallpox and monkeypox. 24 September 2019. https://www.fda.
13. Decker MD, Garman PM, Hughes H, et al. Enhanced safety sur gov/newsevents/pressannouncements/fdaapprovesfirstlive
veillance study of ACAM2000 smallpox vaccine among US mili nonreplicatingvaccinepreventsmallpoxandmonkeypox. Ac
tary service members. Vaccine. 2021;39(39):5541–5547. cessed 15 July 2022.
14. Williams M. Cessation of mandatory anthrax and smallpox 36. CDC. Smallpox prevention and treatment. https://www.cdc.gov/
vaccinations for routine adult immunization medical readiness. smallpox/preventiontreatment/index.html. Accessed 15 July 2022.
Department of the Army. 4 June 2018. https://www.health.mil/ 37. Grosenbach D, Honeychurch K, Rose E, et al. Oral tecovirimat
ReferenceCenter/Policies/2018/06/06/CessationofMandatory for the treatment of smallpox. NEJM. 2018;379(1):44–53.
AnthraxandSmallpoxVaccinationsforRoutineImmunization/. 38. CDC. Comparison of reactions for firsttime vaccinees and re
Accessed 15 July 2022. vaccinees. https://www.cdc.gov/smallpox/clinicians/comparison
15. Pavlin J, Relman DA. An assessment of illness in U.S. government vaccineesimages.html#2. Accessed 15 July 2022.
employees and their families at overseas embassies. Natl Acad
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