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TXA was most beneficial when given with cryoprecipitate. School of Medicine, Columbia University, the Texas Army Na-
In the prehospital assessment of TXA in Afghanistan and tional Guard, Department of the Army, or the Department of
53
Iraq, no survival benefit was determined. However, two re- Defense.
cent studies and a systematic review and meta-analysis found
a mortality benefit from prehospital TXA administration. 54–56 References
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underappreciated for many years. They are now being recog- to achieve zero preventable deaths after injury. 2016. https://nap
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tions from the Joint Trauma System (JTS) and the Committee National%20Academies%20of%20Sciences,of%20zero%20
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requirements. Arginine vasopressin is an option in the pre- 6. Moore HB, Moore EE, Morton AP, et al. Shock-induced sys-
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use in combat has been associated with increased mortality. 903–904.
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15
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Conclusion
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-in-trauma/. Accessed 24 April 2022.
18. Guyette FX, Sperry JL, Peitzman AB, et al. Prehospital blood
Disclosures
The authors have nothing to disclose. product and crystalloid resuscitation in the severely injured pa-
tient: a secondary analysis of the prehospital air medical plasma
trial. Ann Surg. 2021;273(2):358–364.
Disclaimer 19. Kasotakis G, Sideris A, Yang Y, et al. Aggressive early crystalloid
The opinions or assertions contained herein are the private resuscitation adversely affects outcomes in adult blunt trauma
views of the author and are not to be construed as official patients: an analysis of the Glue Grant database. J Trauma Acute
or as reflecting the views of the University of New Mexico Care Surg. 2013;74(5):1215–1221; discussion 1221–1222.

114 | JSOM Volume 22, Edition 2 / Summer 2022