Page 341 - ATP-P 11th Ed

Indications:
• Antihistamine for allergies
• Anaphylactic reactions in addition to epinephrine
• Nausea
• Vomiting
• Motion sickness
• Antiemetic therapy
Adult dose:
• Oral dose
° Nausea/vomiting: The average adult dose is 25mg q4hr.
° Motion sickness: The average adult dose is 25mg bid. The initial dose should be
taken 30 minutes to 1 hour before anticipated travel and be repeated 8–12 hours later
if necessary. On succeeding days of travel, it is recommended that 25mg be given on
arising and again before the evening meal.
• Parenteral: administered by deep IM injection
° Nausea/vomiting: 12.5–25mg q4–6hr PRN. If taking narcotics or barbiturates, it may
be necessary to reduce doses of those medications to prevent excess somnolence. SECTION 3
° Motion sickness: 12.5–25mg; repeat PRN up to 4 times/day
Pediatric dose:
• Oral dose:
° Nausea/vomiting
• 2–12 years old: 1.1mg/kg of body weight. Do not exceed half of the suggested
adult dose.
• Children <2 years old: Contraindicated
• Motion sickness: Contraindicated in children
° Parenteral: administered by deep IM injection
• Nausea/vomiting:
• 2 to 12 years old: 12.5–25mg q4–6hr PRN. If taking narcotics or barbiturates, re-
duce the dose to 1.1mg/kg.
• Motion sickness: Contraindicated in children
Contraindications:
• Children <2 years old
• Comatose states
• Antiemetics should not be used in vomiting of unknown etiology in children.
• Asthma
Pregnancy Category C
Side-effects:
• Drowsiness, sedation, sleepiness
• Anticholinergic effects – dry mouth, urinary retention, dry eyes, constipation
• Photosensitivity

ATP-P Handbook 11th Edition 331