Page 336 - ATP-P 11th Ed

• Hypertension
• Tremors
TMEP use:
• K9 Trauma Management Protocol
• Loss of Consciousness (without seizures) Protocol
®
Nelfinavir (Viracept )
GROUNDING medication for personnel on flight status
Description: Anti-retroviral agent, protease inhibitor
Indications: HIV post exposure prophylaxis
Adult dose: 750mg tid or 1250mg bid if taken with food
Pediatric dose: Children 2–13 years old: 45–55mg/kg bid, or 25–35mg/kg tid
• If tablets are unable to be taken may use powder form mixed with water, milk, formula, or
dietary supplement. Do not use acidic juices. Once mixed, do not store for more than 6 hours.
Contraindications:
SECTION 3 • Hypersensitivity to nelfinavir
• Concurrent therapy with amiodarone, ergot derivatives, midazolam, pimozide, quini-
dine, triazolam
Pregnancy Category B
Adverse reactions:
• Diarrhea (14–20% of adults, 39–47% of children)
• Nausea
• Flatulence
• Rash
• Decreased lymphocytes
• Decreased neutrophils
• Decreased hemoglobin
• Increased creatine kinase
• Increased transaminases
• Abdominal pain
• Weakness
• Other reactions occur at a rate of less than 2%
Other notes:
• Has high potential for interactions with other drugs.
• Not recommended for use with rifampin, St. John’s Wort, lovastatin, simvastatin, or
proton pump inhibitors. Serum levels will be significantly reduced.
• Should be taken with meals to increase plasma concentration.
• If mixed with acidic food or juice (e.g., orange juice, apple juice, applesauce) it may
have a bitter taste.
TMEP use: HIV Post Exposure Prophylaxis Protocol

326 SECTION 3 RECOMMENDED DRUG LIST (RDL)