Page 116 - 2023 SMOG Digital

ACETYLSALICYLIC ACID Lactation Yes (Short Term Trade Name: Aspirin
or Low Dose OK)
Class / Mechanism of Action
Nonsteroidal Anti-inflammatory Drug (NSAID)
Blocks cyclooxygenase (COX 1 and 2) enzymes, resulting in reduced formation of prostaglandin
precursors. Blocks formation of prostaglandin derivative, thromboxane A2, resulting in inhibited platelet
aggregation. Has antipyretic, analgesic, and anti-inflammatory properties.
Indications
Labeled Indications: Treatment of acute coronary syndromes (ST-elevation MI, non-ST-elevation MI,
unstable angina), acute ischemic stroke, and transient ischemic episodes.
Contraindications
• Hypersensitivity to salicylates, other NSAIDs, or any component of the formulation
• Asthma, Rhinitis
• Inherited or acquired bleeding disorders (including factor VII and factor IX deficiency)
• Do not use in children less than 16 years old (Reye's syndrome)
Adverse Reactions / Precautions
• Not for use on trauma patients in the combat environment.
• Risk of bleeding: Avoid use in patients with known or suspected: Bleeding disorders, GI Bleed, GI
Ulcers, patients taking Coumadin, or within 24hr of taking Alteplase (tPA) for suspected stroke
Dose and Administration:
ADULT PEDIATRIC Always Reference BROSELOW Tape
Acute coronary syndrome (ST-segment N/A:
elevation myocardial infarction [STEMI], Contraindicated in children under 16 yrs
unstable angina (UA)/non-ST-segment elevation (Reye’s Syndrome)
myocardial infarction [NSTEMI]): (Not for use in
trauma patients ):
PO:
• 324mg (chew nonenteric-coated aspirin as a
single 325mg tablet or 4 X 81mg tablets)

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