Page 115 - 2023 SMOG Digital

ACETAZOLAMIDE Lactation Yes(Caution) Trade Name: Diamox
Class / Mechanism of Action
Diuretic, Carbonic Anhydrase Inhibitor; Anticonvulsant
Inhibits carbonic anhydrase causing a decrease in hydrogen ion renal secretion with increased renal
secretion of sodium, potassium, bicarbonate, and water. Onset of action PO: 2 hours, IV 5-10 minutes
Indications
Labeled Indications:
• Prevention or treatment of symptoms of acute mountain sickness
• Edema due to congestive heart failure
Contraindications
• Hypersensitivity to acetazolamide, sulfonamides, or any component of the formulation
• Confirmed low sodium/potassium levels otherwise none in emergency setting
Adverse Reactions / Precautions
• May worsen respiratory acidosis
• Drowsiness, deceased alertness, impairment of coordination, nausea, headache
• Flushing of skin, allergic skin reaction, skin photosensitivity
Dose and Administration: ADULT PEDIATRIC Always Reference LB tape
Altitude illness (Acute Mountain Sickness): Altitude illness (Acute Mountain Sickness):
PO: PO: (IM not recommended due to alkaline pH)
• 125-250mg twice daily. • 2.5mg/kg/dose q8-12hr
o MAX dose 250mg/dose.
Note: For high altitude cerebral edema (HACE),
dexamethasone is the primary treatment; however, Note: For high altitude cerebral edema (HACE),
acetazolamide can be used (together with dexamethasone is the primary treatment; however,
dexamethasone) at the AMS dose. acetazolamide can be used (together with
dexamethasone) at the AMS dose.
Edema (Only with referring doctor or medical
director instruction):
PO, IV:
• 250-375mg once daily

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