Page 114 - 2023 SMOG Digital

ACETAMINOPHEN Lactation Yes (Caution) Trade Name: Tylenol
Class / Mechanism of Action
Analgesic
Blocks cyclooxygenase (COX 1 and 2) enzymes, resulting in reduced formation of prostaglandin
precursors. Blocks formation of prostaglandin derivative, thromboxane A2, resulting in inhibited platelet
aggregation. Has antipyretic, analgesic, and anti-inflammatory properties.
Indications
Labeled Indications: Treatment of mild to moderate pain and fever, Treatment of moderate to severe
pain when provided via IV with opioid analgesia
Contraindications
• Hypersensitivity to acetaminophen or any component of the formulation
• Hepatic impairment or liver disease
Adverse Reactions / Precautions
• Use IV form cautiously in volume depleted patients
• Avoid use in patient suffering alcohol toxicity, known alcohol abuse, or renal impairment
• IV form can cause nausea and vomiting (especially in adults), headache
Dose and Administration: ADULT PEDIATRIC Always Reference BROSELOW Tape
Pain or fever: (Limit total daily dose to <4g/day Pain or fever: Children ≥12 years & Adolescents:
PO: Refer to adult dosing
• Regular release: 325-650mg q4-6hr or PO:
1000mg 3-4 times daily (maximum: 4g daily) • Infants and Children <12 years: 10-15mg/
kg/dose q4-6hr as needed; do not exceed
5 doses (2.6g) in 24 hours
RECTAL: RECTAL:
• 325-650mg q4-6hr or 1000mg 3-4 times • Infants and Children <12 years: 10-20mg/
daily (max: 4g daily) kg/dose q4-6hr as needed; do not exceed
5 doses (2.6g) in 24 hours.
IV:
• <50kg: 15mg/kg q6hr IV:
o Max single dose: 15mg/kg/dose • Children 2-12 years: 15mg/kg q6hrs or
(750mg/dose) 12.5mg/kg q4hr
o Max daily dose: 75mg/kg/day (≤3.75g o Max single dose: 15mg/kg/dose
daily) (≤750mg/dose)
• ≥50kg: 1000mg q6hr o Max daily dose: 75mg/kg/day (≤3.75g
o Max single dose: 1000mg/dose daily)

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