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Discussion                                         Disclaimer
                                                             The views expressed in this article are those of the authors and
          This was a very small, simple study using only three units of   do not reflect the official policy or position of the U.S. Army
          non-typed, non-ASBP drawn WB from non-screened volunteer   Medical Department, Department of the Army, Department of
          donors, conducted simply to determine whether maintaining   Defense, or the U.S. Government.
          CWB/blood products at appropriate temperatures with equip-
          ment organic to a Special Forces battalion was feasible during   Funding
          transportation to potential locations of injury throughout the   No funding was received for this work.
          shelf-life of the storage bag.
                                                             References
          As expected, there were variations in temperatures for those   1.  Pierce S. Blood  Transfusion in the First  World  War. Univer-
          bags removed from fixed (electronically powered) refrigera-  sity Of Kansas Medical Center; 2019.  https://www.kumc.edu/
          tion units, but no incidents that would have led to “wasting”   school-of-medicine/academics/departments/history-and-
          of products. This study demonstrates an internal validity of   philosophy-of-medicine/archives/wwi/essays/medicine/
          our ability to appropriately manage cold blood if procured.   blood-transfusion.html
          Additional blood storage devices in the form of APRUs, Blood-  2.  Blood  Transfusion on the Battlefield: Blood Plasma. National
          Boxx, and purpose-built blood refrigerators will be required if   WWII Museum;2017.  https://www.nationalww2museum.org/
                                                                sites/default/files/2017-07/blood-plasma-fact-sheet.pdf
          these findings are to be expanded and applied at a larger scale.  3.  Thompson PT, Standenes G. The history of fluid resuscitation
                                                                for bleeding. In: Spinella PC, ed. Damage Control Resuscitation.
          The process of procuring FDA-approved  WB products for   Springer; 2020. doi:10.1007/978-3-030-20820-2_1
            real-world use during training emergencies in the U.S. is the   4.  Coulthard SL, Kaplan LJ, Cannon JW. What’s new in whole blood
          next significant hurdle. Coordination for scheduling blood   resuscitation? In the trauma bay and beyond. Curr Opin Crit Care.
                                                                2024;30(3):209–216. doi:10.1097/MCC.0000000000001140
          donation events at the unit level and as well as coordination   5.  Spinella PC, Pidcoke HF, Strandenes G, et al. Whole blood for
          with local ASBPs will be required to support this advancement   hemostatic resuscitation of major bleeding. Transfusion. 2016;56
          of care. An ancillary, but advantageous outcome may be an   Suppl 2:S190–S202. doi:10.1111/trf.13491
          increased supply of the unfortunately depleted supplies of do-  6.  Taylor AL,  Corley JB,  Cap AP,  et al. The  U.S. Armed  Services
          nor blood for Armed Service Blood Banks (ASBB) at large and   Blood Program support to U.S. Central Command 2014-2021:
          contingency blood supplies also throughout the multiple com-  transformation of combat trauma resuscitation through blood
          batant commands they support. As it stands today, multiple   product innovation and expansion of blood availability far for-
                                                                ward.  Transfusion. 2022;62 Suppl 1:S167–S176. doi:10.1111/
          regulatory processes overseen by the FDA, ASBP, and other   trf.16951
          governing bodies limit the ability of blood products that go   7.  Zhu CS, Pokorny DM, Eastridge BJ, et al. Give the trauma pa-
          unused by SOF units to be rotated back into the military hos-  tient what they bleed, when and where they need it: establishing
          pitals’ use cycle. For clarity, if a hospital or donation center   a  comprehensive  regional  system  of  resuscitation  based  on  pa-
          issues blood to a SOF unit, they must consider it “wasted”   tient need utilizing cold-stored, low-titer O+ whole blood. Trans-
          since they will not be allowed to accept its return under most   fusion. 2019;59(S2):1429–1438. doi:10.1111/trf.15264. PMID:
                                                                30980748
          circumstances. As hospitals and blood banks are charged with   8.  Shackelford SA, Gurney JM, Taylor AL, et al. Joint Trauma Sys-
          ensuring the best use of this scarce resource, this may serve   tem, Defense Committee on Trauma, and Armed Services Blood
          as a barrier to routine issuing of WB to SOF Operators. With   Program consensus statement on whole blood. Transfusion. 2021;
          this study demonstrating the ability of SOF medics to store   61 Suppl 1:S333–S335. doi:10.1111/trf.16454
          and handle blood at appropriate temperatures throughout its   9.  Voller J, Tobin JM, Cap AP, et al. Joint Trauma System clinical
          shelf-life, and the subsequent development of a pilot program   practice guideline (JTS CPG): prehospital blood transfusion.
          between Armed Services Blood Bank Center – Pacific North-  30 October 2020. J Spec Oper Med. 2021;21(4):11–21. doi:10.
                                                                55460/P685-L7R7
          west and 2nd Bn 1st SFG(A) to incentivize donations and im-  10.  Cap AP, Beckett A, Benov A, et al. Whole Blood Transfusion (CPG
          plement continuous access to CWB at JBLM, it is our hope   ID:21). Joint Trauma System Clinical Practice Guideline. May 15,
          that a discussion can be initiated about allowing hospitals to   2018. Accessed  June 19, 2025. https://jts.health.mil/assets/docs/
          accept unused blood back from SOF units and, by extension,   cpgs/Whole_Blood_Transfusion_15_May_2018_ID21.pdf
          further remove some of the barriers in access to CWB at the   11.  Song KH, Winebrenner HM, Able TE, et al. Ranger O Low Titer
          point of injury in CONUS training environments.       (ROLO): whole blood transfusion for forward deployed units.
                                                                Mil Med. 2021;10:usab473. doi:10.1093/milmed/usab473
                                                             12.  Eliassen HS, Hervig T, Backlund S, et al. Immediate effects of blood
          Conclusion                                            donation on physical and cognitive performance–A randomized
                                                                controlled double-blinded trial. J Trauma Acute Care Surg. 2018;84
          The results show there were no cases of mishandling or require-  (6S Suppl 1):S125–S131. doi:10.1097/TA.0000000000001917
          ment to waste blood products prematurely due to tempera-  13.  Jones TB, Moore VL, Shishido AA. Prehospital whole blood in
          tures falling outside of appropriate ranges. This demonstrates   SOF: current use and future directions. J Spec Oper Med. 2019;19
                                                                (4):88–90. doi:10.55460/Q12Y-6Y8I
          the feasibility of maintaining CWB and other cold-stored   14.  Bauernfeind TD. Vol Policy Memorandum 20-18, Special Oper-
          blood products at the operational level in SOF, which brings   ations Low-Titer O Whole Blood Program. USSOCOM; 2020.
          us one step closer to putting this life-saving treatment in the   15.  Fisher H.  Trends in  Active-Duty Military Deaths From 2006
          hands of our well-trained medics and providers at the point of   Through 2021. Congressional Research Service; 2022.
          injury for use on severely injured Operators at training events
          in CONUS.                                          PMID: 40552986; DOI: 10.55460/QCA3-5N0M

          Disclosures
          The authors have indicated they have no financial relation-
          ships relevant to this article to disclose.


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