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FIGURE 1  Flow chart of participants.

                       VA PRC Participants as of 6/30/2022
                                  n=1,876                           Excluded: n=463
                                                                           n=389  SOF variable did not exist
                                                                           n=3    Refused
                                                                           n=63   SOF Unknown
                                                                           n=8    Missing SOF Data
                          Participants with SOF status
                                  n=1,413                           Excluded: n=222
                                                                           n=81   No PCL­C data at any time point
                                                                           n=141   Missing data for any variable
                                                                                  used to match samples: age, sex,
                                                                                  race, education, TBI severity, and
                        Participants with SOF status and                          days from TBI to admission.
                           ≥1 PCL­C at any time point
                                  n=1,191
                               No SOF n=778
                               Yes SOF n=413


                     Matched participants with SOF status and
                           ≥1 PCL­C at any time point
                                   n=410
                                 SOF n=205
                                  CF n=205




              We compared our matched SOF sample (n=205) to the total   those with moderate TBI, SOF and CF with severe TBI had
              SOF sample (n=413) on PCL-C scores across all time points.   lower PCL-C scores at enrollment (CF, mean 28; SOF, mean
              The total SOF sample had mildly elevated PCL-C scores com-  31) relative to the 5-year post-TBI follow-up (CF, mean 35;
              pared to the matched SOF sample; however, all differences be-  SOF, mean 38).
              tween total SOF sample and matched SOF sample were less
              than 4.6 points and not statistically  significant (results not   Discussion
              shown). Thus, differences observed between the total SOF and
              matched SOF groups are small in magnitude and less than the   This study examined the trajectory of PTSD symptoms among
                                                        30
              minimal clinically important difference for the PCL-C.  This   SOF with a history of TBI as compared to a matched sample
              finding indicates the matched SOF group had similar levels of   of CF. Results indicated that symptoms of posttraumatic stress
              PTSD symptoms as the total SOF group at all time periods.  among SOF with histories of TBI were statistically similar to
                                                                 those of CF with histories of TBI.
              Figure 2 displays the PCL-C scores over time stratified by TBI
              severity. When examining the longitudinal model, SOF and CF   For SOF and CF with mild TBI, symptoms remained relatively
              have similar levels and patterns of PTSD symptoms across TBI   stable, with PCL-C scores close to the cutoff for probable
              severities and over time. None of the observed differences be-  PTSD (>49) up to 10 years post TBI. For moderate and severe
              tween SOF and CF for a given time point exceeded 9 points   TBI, PTSD symptoms at the group level increased after 5 years
              on the PCL-C (Table 2), which was not statistically significant   post TBI. Mild TBI was associated with higher levels of PTSD
              (P=.594).  Statistically  significant  predictors  of  PTSD  symp-  symptoms, possibly because moderate and severe TBIs can dis-
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              toms included more time since TBI (P<.001), less severe TBI   rupt the consolidation of the trauma memory.  Particularly
              (P<.001), and previous MH treatment (P<.001). Problematic   concerning is that across all TBI severity levels, PTSD symp-
              substance use was not significant, nor were any of the model   toms did not decrease with time, indicating that SOF and CF
              interactions (P>.05; Table 3).                     will need access to PTSD treatments for at least 10 years after
                                                                 their brain injuries. Comparing the total SOF sample to the
              When examining PTSD symptom severity, SOF and CF with   matched SOF sample demonstrated that elevated PTSD symp-
              mild TBI had higher mean PCL-C scores across all time points   toms were not merely a by product of the matching process, as
              (baseline and 1, 2, 5, and 10 years post TBI) compared with   both samples had similar levels of PTSD symptoms. Because
              moderate and severe TBI groups (Table 2). PCL-C scores for   most of the extant literature on PTSD after TBI has focused on
              the mild TBI groups (SOF and CF) were consistently elevated   CF, we will focus our discussion on SOF.
              at enrollment (CF, mean 43; SOF, mean 47) and the 10-year
              post-TBI follow-up (CF, mean 48; SOF, mean 45). SOF and   Despite perpetuated assumptions,  the findings from this
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              CF with moderate TBI had lower PCL-C scores at enrollment   study indicated SOF experience similar levels of PTSD symp-
              (CF, mean 32; SOF, mean 36) and had higher scores at the   toms following TBI as their CF colleagues. This finding has
              5-year post-TBI follow-up (CF, mean 49; SOF, mean 41). Like   several implications for healthcare systems serving SOF. Both

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