Page 76 - JSOM Spring 2024
P. 76
similar purification tasks. These commercially available de- Conclusion
vices vary greatly in size, weight, cost, and volume of water
throughput. Six different methods of water purification were Based on the results of this study and the feedback received
evaluated and found to effectively reduce the bacterial burden from experienced military physicians, we conclude that a
in water. However, no single device was perfect, as each device layered approach to water purification is optimal. Notably,
had both perceived strengths and weaknesses. CHLOR-FLOC, the product the U.S. Military has used since
WWII, has many desirable characteristics and effectively re-
duces microbial load in contaminated water. In austere settings
Severe, open, battlefield wounds are inherently prone to in-
fection because of their exposure to the environment, con- where all equipment is manually carried, given its high-volume
tamination with dirt and debris, and blood loss/transfusion. throughput, low cost and cube, and positive effects on pH and
11
Irrigation with fluids is a primary strategy to remove debris water decontamination, the Aquamira drops appear superior
and reduce infection. Accordingly, it is crucial to ensure that to the other small, lightweight products. When weight, cost,
12
no additional bacteria are introduced via contamination with and cube are less important (vehicle availability), the Guardian
dirty water. All the evaluated products significantly decreased purifier appears to be a superior device.
the CFUs of all contaminated water sources (pond and river
water and inoculated saline), but only the Steripen device re- Author Contributions
duced bacteria levels to below detectable limits. NM, DJS, and JCW conceived the study. IBH and SMS co-
ordinated, collected, and analyzed the data. IBH, SMS, JBH,
and JCW wrote the first working drafts of the manuscript. All
It is generally understood that human pathogenic bacteria
thrive in alkaline environments; as such we measured pH in authors read, edited, and approved the final manuscript.
13
the pond, river, and tap waters used in this study. The use
of filtration or boiling decreased the already alkaline pH of Disclaimer
the pond, river, and tap water, whereas chemical purification The views expressed in this article are those of the author(s)
methods raised the acidity of the water. Accordingly, chemical and do not reflect the official policy or position of the U.S.
purification may be preferred to filtration. Army Medical Department, Department of the Army, DoD, or
the U.S. Government.
Turbidity reflects the “cloudiness” or individual particles
in any water source and generally indicates the presence of Disclosures
pathogenic microorganisms. As expected, pre-treatment tur- Dr. Holcomb is a consultant with BARDA, Aspen medical and
14
bidity measurements indicate that only pond and river water DoD, is Co-founder, Co-CEO and a Member of the Board of
sources were more turbid than saline or tap water sources. The Directors of Decisio Health, the Board of Directors of He-
Guardian and CHLOR-FLOC methods decreased the turbid- mostatics, QinFlow, Zibrio, and Oxyband. He is also a Co-
ity of both river and pond water. inventor of the Junctional Emergency Tourniquet Tool.
Given the lack of conclusive data from high-quality clinical tri- References
als, the optimal combination of CFU count, turbidity, and pH 1. Svoboda SJ, Owens BD, Gooden HA, Melvin ML, Baer DG, Wenke
JC. Irrigation with potable water versus normal saline in a con-
for high-volume wound irrigation is unknown. A multicenter, taminated musculoskeletal wound model. J Trauma. 2008;64(5):
randomized, prospective clinical study of 634 patients with 1357–1359.
lacerations identified no differences in infection outcomes be- 2. Owens BD, White DW, Wenke JC. Comparison of irrigation solu-
tween saline and tap water irrigation. 15 tions and devices in a contaminated musculoskeletal wound sur-
vival model J Bone Joint Surg Am. 2009;91(1):92–98.
Characteristics, such as flow rate, cost, volume, and size/weight 3. Blanchette KA, Wenke JC. Current therapies in treatment and
of purification devices, are important metrics to consider for prevention of fracture wound biofilms: Why a multifaceted ap-
proach is essential for resolving persistent infections. J Bone Jt
use in austere military and civilian settings. These vary greatly Infect. 2018;3(2):50–67.
in the products we evaluated. Current recommendations for 4. Sloan BK, Mohammad H, Abutaleb NS, Seleem MN. Compar-
wound irrigation specify using up to 10L per wound. The ison between a novel tap water wound irrigation device with
4
Guardian purifier had the highest capacity; however, it was the sterile saline device in an open traumatic wound animal model.
most expensive and the largest of the methods evaluated. At Trauma. 2020;22(3):176–181.
the other end of the spectrum, the Aquamira was inexpensive 5. Wilderness Medical Society. WMS: Water Disinfection Guidelines •
Survive Student Resource (austererisk.com) Wilderness Medical So-
and lightweight but delivered a high volume of fluid, which ciety Clinical Practice Guidelines for Water Disinfection for Wilder-
would facilitate treatment of multiple casualties. Other prod- ness, International Travel, and Austere Situations. Survive First Aid.
ucts fall between these devices in terms of desirable features. Published May 2021. Accessed 19 Feb 2023. https://survive-student-
Balancing flow rate, cube, and cost of the selected device de- resource.austererisk.com/general/wms_water_disinfection.html.
pends on tactical and logistical considerations. 6. Potable Aqua. Accessed February 7, 2024.https://pharmacalway.
com/potableaqua/.
7. Fernandez R, Green HL, Griffiths R, Atkinson RA, Ellwood LJ.
Limitations Water for wound cleansing. Cochrane DatabaseSyst Rev. 2022;
The results of the current study should be interpreted in light (9):CD00386.
of several limitations. It was not possible to test the water 8. Chang SL, Morris JC. Elemental iodine as a disinfectant for
sources for viruses, protozoa, chemicals, and toxins. Instead, drinking water. IndEng Chem. 1953;45(5):1009–1012.
we relied on the manufacturers’ descriptions. Notably, the 9. Gorski L, Rivadeneira P, Cooley MB. New strategies for the enu-
product claims were evaluated and found accurate. The most meration of enteric pathogens in water. Environ Microbiol Rep.
2019;11:765–776.
important limitation was that this study only evaluated in vitro 10. Goodner KL. Estimating Turbidity (NTU) From Absorption Data.
results and not in vivo or clinical outcomes, thus only assump- Synergy Sensus Technical Note (SEN-TN-0010). Synergy Fla-
™
tions can be made about the products’ clinical effectiveness. vors; 2009.
74 | JSOM Volume 23, Edition 1 / Spring 2024