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skin. Methicillin-resistant S pseudintermedius (MRSP)   successfully prevent the canine from inflicting further self-
                     is increasing in prevalence and importance in canine   trauma. Early and appropriate treatment leads to the best
                     superficial pyoderma.  For cases involving a secondary   prognosis with rapid improvement and resolution usually
                                     9
                     superficial pyoderma in which topical antiseptics have   within 3–7 days. If the lesion is not allowed to fully heal or if
                     failed to resolve the infection, consider application   the primary underlying problem is not addressed or managed
                     of topical mupirocin, an antibacterial agent effective   appropriately, there is high likelihood that the itch-scratch cy-
                     against most MRSP isolates.  Due to the increasing   cle will recur and the hot spot will relapse.
                                           9
                     resistance to methicillin-resistant S aureus (a pathogen
                     of concern in people), it is recommended to reserve the   Prevention
                     use of mupirocin for targeted therapy and when based
                     on culture and susceptibility testing. 9    Prevention  is  based  on  understanding  why  hot  spots  occur,
                                                                 what primary underlying conditions may lead to self-inflicted
              Important notes:                                   trauma, and what measures are required to prevent these un-
                •  Whenever possible, topical agents are best applied as   derlying causes from spiraling out of hand. The risk for devel-
                  nonocclusive vehicles (e.g., sprays, rinses, gels).  Avoid   oping a hot spot is substantially reduced by keeping up with
                                                        1
                  medications formulated in occlusive vehicles (e.g., oint-  grooming, bathing, and environmental hygiene; maintaining
                  ments, creams) because these may clog hair follicles and   ectoparasite control; routinely inspecting and cleaning the
                  promote formation of bacterial folliculitis.   canine’s ears; and routinely examining and expressing anal
                •  Combination therapy: One study revealed that use of a   glands as needed. If the OpK9 has a known history of allergic
                  product combining an antimicrobial with a corticosteroid   skin diseases, ensure they remain up to date on their prescrip-
                  (namely, neomycin-prednisolone) provided faster resolu-  tion medications/diet and avoid exposures to potential trig-
                  tion than either agent used alone. Betagen  (gentamicin   gers that may exacerbate these conditions. For OpK9s with
                                                   ®
                                            6
                  sulfate/betamethasone valerate; Med-Pharmex, https://  a history of hot spots, be alert to excessive licking, chewing,
                  www.medpharmex.com) is a commonly used commercial   and or scratching. Preemptively consult a veterinary behavior-
                  veterinary product used for pyotraumatic dermatitis.  ist to use appropriate behavior modification techniques (e.g.,
                                                                 desensitization) for OpK9s that display or have a high risk of
              Systemic Therapy 1,2,5,8–10                        suffering self-directed behavior due to environmental or social
              Topical  therapy  alone  (particularly  daily  cleaning  and dry-  stressors.
              ing) in conjunction with physically blocking additional self-
              inflicted trauma is generally effective for resolving mild cases   Disclosure
              of pyotraumatic dermatitis. Moderate to severe cases and   The author has indicated he has no financial relationships rel-
              cases involving a secondary superficial or deep pyoderma of-  evant to this article to disclose.
              ten require additional systemic therapy.
                                                                 References
                                                                 1.  Rosenkrantz WS. Web Chapter 42: Pyotraumatic dermatitis
                •  Corticosteroids reduce inflammation and pruritus. Due
                  to the intensely pruritic and inflammatory nature of the   (‘Hot Spots’). In: Bonagura JD and Twedt DC., eds. Kirk’s Cur-
                                                                    rent Veterinary Therapy XV. St. Louis, MO: Elsevier Saunders;
                  hot spots, some dogs benefit from a short course of an   2014:e206.
                  oral antiinflammatory drug. Avoid long-acting cortico-  2.  Miller WH, Griffin CE, Campbell KL. Chapter 16: Environmen-
                  steroids (e.g,. injectable repositol); instead, use short- to   tal skin diseases. In: Muller and Kirk’s Small Animal Dermatol-
                  intermediate-acting  drugs (e.g.,  prednisone  0.5mg/kg/  ogy. 7th ed. St. Louis, MO: Saunders Elsevier; 2013:677–678.
                  day administered every 12–24 hours orally [PO] for 3–5   3.  Virga V. Self-directed behaviors in dogs and cats. 2015. http://
                  days).                                            veterinarymedicine.dvm360.com/self-directed-behaviors
                                                                    -dogs-and-cats?id=&pageID=1&sk=&date= Accessed 17 Febru-
                •  Antimicrobial medications  are used to  treat known or   ary 2018.
                  highly suspected bacterial pyoderma, pyotraumatic fol-  4.  Hoffmann AR, Patterson AP, Diesel A, et al. The skin microbiome
                  liculitis, or furunculosis. Ideally, selection of an appropri-  in healthy and allergic dogs. PLoS One. 2014;9(1):e83197.
                  ate systemic antimicrobial agent is based on culture and   5.  Holm BR, Rest JR, Seewald W. A prospective study of the clinical
                  sensitivity testing; however, this is not readily available in   findings, treatment and histopathology of 44 cases of pyotrau-
                                                                    matic dermatitis. Vet Dermatol. 2004;15:369–376.
                  a field environment. Because MSRP is becoming a very   6.  Schroeder H. Efficacy of topical antimicrobial-anti-inflammatory
                  common pathogenic skin bacterium associated with pyo-  combination in the treatment of pyotraumatic dermatitis in dogs.
                  derma in dogs, initial empirical therapy should target this   Vet Dermatol. 1996;7:163.
                  genus of gram-positive bacteria. In a study in which 44   7.  DeBoer DJ. Skin scraping for external parasites. Clinicians Brief.
                  cases of pyotraumatic dermatitis in dogs were evaluated,   2016;April:43–47.
                  there was a high rate of Staphylococcus resistance to pen-  8.  Kersey KM, Rosales M, Roberts BK. Dermatologic emergencies:
                  icillin and ampicillin but a very low rate of resistance to   identification and treatment. Compend Contin Educ Vet. 2013;
                                                                    35(1):E2.
                  cephalexin.  For empirical therapy, consider a cephalo-  9.  Hillier A, Lloyd DH, Weese JS, et al. Guidelines for the diagnosis
                           5
                  sporin (cephalexin 20–30mg/kg PO every 12 hours for   and antimicrobial therapy of canine superficial bacterial folliculi-
                  7 days) or potentiated aminopencillin (amoxicillin-clavu-  tis (Antimicrobial Guidelines Working Group of the International
                  lanic acid 15–20mg/kg PO every 8–12 hours for 7 days). 9  Society for Companion Animal Infectious Diseases). Vet Derma-
                                                                    tol. 2014;25:163–e43.
                                                                 10.  Summers JF, Brodbelt DC, Forsythe PJ, et al. The effectiveness of
              Prognosis                                             systemic antimicrobial treatment in canine superficial and deep
                                                                    pyoderma: a systematic review. Vet Dermatol. 2012;23:305–e61.
              Prognosis depends on the (1) compliance, commitment, and   11.  Reinke SI, Stannard AA, Ihrke PJ, et al. Histopathologic features
              ability to keep up with daily treatments; (2) success in deter-  of pyotraumatic dermatitis. J Am Vet Med Assoc. 1987;190(1):
              mining and treating the underlying cause; and (3) ability to   57–60.

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