Page 151 - 2026 SMOG

MOXIFLOXACIN (AVELOX)
Class/Mechanism of Action
• Antibiotic (Fluoroquinolone)
Bactericidal—DNA gyrase inhibitor and topoisomerase IV inhibitor—which is an essential
enzyme that maintains the superhelical structure, replication, transcription, and repair of
bacterial DNA.
Indications
• Labeled Indications
˚ Used for infection control prophylaxis for traumatic open injuries and surgical prophylaxis
Contraindications
• Hypersensitivity to moxifloxacin, other quinolone antibiotics, or any component of the
formulation
Adverse Reactions/Precautions
• Superinfection—prolonged use may result in fungal or bacterial superinfection (including
C.Difficile)
• May cause QT prolongation
• Avoid use in known aortic aneurysm or dissection
• Pregnancy: Safe for use; dosage may need to be increased in late-stage pregnancy.
• Lactation: Unknown
Dose/Administration
PEDIATRIC
ADULT
(Always reference Broselow Tape)
Infection Control Infection Control
• PO • PO
˚ 400mg once daily (max DAILY dose: ˚ ˚ Maximum dose: 200mg/dose
>3mo–2y/o: 6mg/kg q12hr
400mg/day)
˚ 2–<6y/o: 5mg/kg q12hr
˚ 6–<12y/o: 4mg/kg q12hr
˚ >12y/o (<45kg): 4mg/kg q12hr
˚ >12y/o (>45kg): Refer to adult dosing

2026 Standard Medical Operating Guidelines (SMOG) • 143