Page 146 - 2026 SMOG

METHYLPREDINISOLONE (SOLUMEDROL)
Class/Mechanism of Action
• Systemic Corticosteroid
Anti-inflammatory, immunosuppressant, shock.
Indications
• Labeled Indications
˚ Treatment of a variety of diseases: allergic, inflammatory, hematologic, neoplastic, and
autoimmune
• Off-Label Indications
˚ None identified unless added by medical direction
Contraindications
• Hypersensitivity to methylprednisolone or any component of the formulation
• No other in an emergency setting
Adverse Reactions/Precautions
• Not for use in treatment of head injury; increased mortality has occurred in head injury patients
treated with high-dose IV methylprednisolone.
• No immediate effect will be observed while treating in the pre-hospital environment. Onset of
action may take several hours.
Dose/Administration
PEDIATRIC
ADULT
(Always reference Broselow Tape)
Asthma Exacerbations (Including Status Anaphylaxis/Asthma Exacerbations
Asthmaticus)/Allergic Reaction (Including Status Asthmaticus)/
• IV Allergic Reaction
˚ 125mg × 1 dose • IV
Note: Only methylprednisolone sodium ˚ Children & Adolescents: 2mg/kg initial
succinate can be used for IV doses dose; followed by 1–2mg/kg/day divided
over q6–12 hours (Max daily dose,
120mg)
Note: Only methylprednisolone sodium
succinate can be used for IV doses

138 • MEDICATIONS