Page 147 - 2026 SMOG
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METOCLOPRAMIDE (REGLAN)
                              Class/Mechanism of Action
         •  Prokinetic Agent: Antiemetic, Upper GI Stimulant
           Potent dopamine-receptor antagonist. At higher doses, it blocks serotonin receptors in
           chemoreceptor trigger zones of the CNS. Increases GI tract motility and gastric emptying.
              ˚  Onset of action—IV: 1–3min; Duration—IV: 1–2hr
                                    Indications
         •  Labeled Indications
              ˚  Prevention of postoperative nausea and vomiting; acid Reflux/heartburn/GERD; migraine
             headache
                                  Contraindications
         •  Hypersensitivity to glucagon or any component of the formulation
         •  Insulinoma/Pheochromocytoma
         •  History of tardive dyskinesia
                            Adverse Reactions/Precautions
         •  Tardive dyskinesia
         •  Dystonic reaction to Metoclopramide in the past
         •  GI Obstruction or Hemorrhage
         •  Seizure disorder (epilepsy)
                                Dose/Administration
                                                    PEDIATRIC
                      ADULT
                                              (Always reference Broselow Tape)
         Nausea/Vomiting                 Not recommended or approved for routine
         •  IV/IO                        pediatric use
              ˚  5–10mg over 3min q6–8hr prn
             (max TOTAL dose: 30mg)
         Note: Rapid IV push may cause intense
         feelings of anxiety and restlessness
         Note: Ideal administration to prevent agitation/
         adverse effects: Dilute in a 50 or 100mL NS
         bag and infuse over 10–15min















                          2026 Standard Medical Operating Guidelines (SMOG)  •   139
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