Page 186 - 2022 Ranger Medic Handbook

PSEUDOEPHEDRINE (SUDAFED)
Class: Autonomic nervous system agent–sympathomimetic; alpha/beta-adrenergic agonist, decongestant
Action: Sympathomimetic amine that produces decongestion of respiratory tract mucosa by stimulating the sym-
pathetic nerve endings including alpha-, beta-1 and beta-2 receptors causing vasoconstriction; Stimulates beta-
androgenic receptors causing bronchial relaxation and increasing heart rate and contractility
Dose: 30–60mg PO q4–6hr OR 120mg XR PO q12hr
Onset/Peak/Duration: Onset in 30 minutes/Peak in 1–2 hours/Duration of 3–8 hours
Indications: Symptomatic relief of nasal and eustachian tube congestion, rhinitis, and sinusitis; promotes nasal sinus
drainage and relief on sinus congestion
Contraindications: Sympathomimetic amine hypersensitivity; severe hypertension; coronary artery disease; MAOIs;
glaucoma; hyperthyroidism; BPH; pregnancy category avoid use during 1st trimester and caution advised during 2nd
and 3rd trimesters in pregnancy. May occasionally use and while breastfeeding.
Adverse/Side-effects: Stimulation, tremulousness, difficulty voiding; arrhythmias, palpitation, tachycardia; nervous-
ness, chest tightness, dizziness, headache, sleeplessness, numbness; anorexia, dry mouth, nausea, vomiting, dia-
SECTION 4 Interactions: Sympathomimetics and β-blockers increase pressor effects and toxicity; MAOIs may precipitate hyper-
phoresis, restlessness; heart palpitations when given with pre-workout
tensive crisis; decreases antihypertensive effects of guanethidine, methyldopa, reserpine; avoid use with pre-workout
Note: Do not allow open access to this medication

RABEPRAZOLE (ACIPHEX)
Class: GI agent – proton pump inhibitor (PPI)
Action: Gastric PPI that specifically suppresses gastric acid secretion by inhibiting the H + , K + -ATPase enzyme system
(the acid [proton H + ] pump) in the parietal cells of the stomach; does not exhibit H 2 -histamine receptor antagonist
properties
Dose: 20mg PO qd
Indications: For healing and maintenance of erosive or ulcerative gastroesophageal reflux disease (GERD), duodenal
ulcers, and hypersecretory conditions
Contraindications: PPI hypersensitivity; pregnancy category caution advised during pregnancy and consider alterna-
tive while breastfeeding
Adverse/Side-effects: Headache; Stevens-Johnson syndrome, toxic epidermal necrolysis, erythema multiforme
Interactions: May decrease absorption of ketoconazole; may increase digoxin levels

172 SECTION 4 RANGER MEDIC PHARMACOLOGY & FORMULARY