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common.  While  most  SSTIs  are  managed  on  an  outpatient
          basis, if not recognized and treated appropriately, sepsis and   BOX 3  Readily Available Sepsis and Critical Care Management
                                                              Resources
          life-threatening shock can develop. Cellulitis and abscesses ac-  Joint  Trauma System (JTS) Clinical Practice Guidelines (CPG).
          count for over two-thirds of all active-duty SSTI diagnoses and   Most up to date CPGs available at: https://jts.health.mil/index.cfm/
          most hospital admissions for SSTI. The most common site is   PI_CPGs/cpgs or at https://deployedmedicine.com
          the lower extremity (33.6%), followed by the upper extremity   • Tactical Combat Casualty Care (TCCC) Guidelines
          (28.3%), trunk (14.2%), other or unspecified location (12.4%),   • Prolonged Casualty Care Guidelines
                                        28
          and the head/face/neck region (11.5%).  Lower extremity SSTI   • Sepsis Management in Prolonged Field Care
          are often missed, because caregivers do not examine the lower   • Infection Prevention in Combat-related Injuries
          legs, feet or between toes during initial physical examinations.  • Documentation In Prolonged Field Care
                                                              • Airway Management in Prolonged Field Care
                                                              • Nursing Intervention in Prolonged Field Care
                                                              • Telemedicine Guidance in the Deployed Setting
           BOX 2  Potential Causes of Sepsis
           Head and neck infections                           Other Relevant Resources:
           • Peritonsillar cellulitis and abscess             • Evans L, Rhodes A, Alhazzani W, et al. Surviving Sepsis campaign:
           • Submandibular abscess and Ludwig angina           International guidelines for management of sepsis and septic
           Pulmonary infections                                shock 2021. Crit Care Med. 2021;49(11):e1063–e1143.
           • Bacterial pneumonia                              • Carr MJ, Maves RC. Infectious disease pearls for maritime surgical
           • Coronavirus disease 2019 (COVID-19)               teams. In:  Tadlock MD, Hernandez  AA, eds. Expeditionary
                                                               Surgery at Sea: A Practical Approach. Springer; 2023:267–285.
           Gastrointestinal infections                        • Biberston JD, Darling JA, Tripp MS. Maritime prolonged casualty
           • Appendicitis                                      care. In: Tadlock MD, Hernandez AA, eds. Expeditionary Surgery
           • Sigmoid diverticulitis                            at Sea: A Practical Approach. Springer; 2023:611–626.
           • Cholecystitis                                    • Burkholder T. Alone and unafraid: the independent duty corpsman
           • Cholangitis                                       at sea. In:  Tadlock MD, Hernandez  AA, eds. Expeditionary
           Skin and soft tissue infections                     Surgery at Sea: A Practical Approach. Springer; 2023:173–188.
           • Cellulitis
           • Abscess
           • Pilonidal abscess                               The patient in this scenario required vasopressor support for
           • Perirectal/perianal abscess                     persistent low blood pressure related to septic shock, despite
           • Necrotizing soft tissue infection               appropriate crystalloid resuscitation. In this situation, Nor-
           Urinary tract infection                           epinephrine is the first-line vasopressor recommended. Unfor-
           • Cystitis                                        tunately, only epinephrine is available on destroyers (in vials
           • Pyelonephritis                                  with a 1:1,000 concentration).  Therefore, Role 1 maritime
           Gynecologic infection                             caregivers must understand how to mix an epinephrine drip
           • Bartholin abscess                               and estimate the μg/min being administered by calculating the
           • Pelvic inflammatory disease (e.g., tubo-ovarian abscess)
                                                             drip rate (Table 2). Correctly mixing and administering a va-
                                                             sopressor drip by calculating the drip rate requires training
          Most SSTIs are caused by  Staphylococcus  or  Streptococcus   before deployment. Box 1 lists other necessary procedures in
          species, typically acquired when military members live and   this scenario that also require specific training before being
          work together in deployed or training environments. Risk   performed in an austere environment.
          factors for SSTI include crowded living conditions, infrequent
          bathing and hand washing, trauma (including minor skin   While vasopressors are routinely started through peripheral
          abrasions), skin colonization, and environmental contamina-  IVs in an emergency, central venous access is routinely obtained
          tion, all common in the deployed shipboard environment.    if prolonged vasopressor use is required. However, in the aus-
                                                         29
          The incidence of SSTI in the deployed maritime environment is   tere setting, most Role 1 caregivers lack the supplies and the
          not known. However, a 2011 study of 400 Sailors and Marines   skillset to obtain central venous access. Therefore, peripheral
          during a 3-week underway period found that 49.5% were col-  antecubital access is acceptable. However, the access site MUST
          onized with Staphylococcus aureus and 3.5% with methicillin-   be inspected with every vital sign check for evidence of infiltra-
                               30
          resistant S. aureus (MRSA).  For comparison, as many as 30%   tion of the vasopressor into the surrounding tissues. Infiltration
                                                31
          of the U.S. population in colonized with S. aureus  and MRSA   typically manifests as swelling, redness, or induration at the ve-
          colonization rates of 1%–3% have been reported in different   nous access sight; it can cause permanent damage to the vessel
          industrialized countries. 32                       or even compartment syndrome to the extremity.
          Many potential causes of sepsis (Box 2) require surgical or   In addition to norepinephrine, several medications, supplies,
          procedural source control, which is typically not possible on   and equipment recommended in this scenario are unavailable
          Role 1 capable warships and submarines. However, superficial   on U.S. Navy destroyers, cruisers, or submarines. These include
          skin and soft tissue abscesses, pilonidal abscesses, and peri-  ultrasound, electrocardiogram, three-lead cardiac monitor-
          rectal abscesses may all be encountered in deployed environ-  ing, nasogastric tubes, IV hydrocortisone, and subcutaneous
          ments and Role 1 caregivers should be prepared to perform   heparin. To prepare Independent Duty Corpsmen to perform
          routine incision and drainage either to prevent the progression   PCC during LSCO or routine Distributed Maritime Opera-
          of infection to sepsis or for possible source control when rapid   tions, we identified four changes to the Role 1 capable warship
          MEDEVAC is not possible. Box 3 lists the key references used   Authorized Medical Allowance List (AMAL) that should be
          to develop this scenario for those interested in further reading;   considered.
          these are easily accessed electronically or via military treat-
          ment facility libraries and should be readily available when   First, it is hard to argue that norepinephrine or IV hydrocor-
          deployed in the austere maritime environment. 3,4,7,10,20,21,33–37  tisone should be included on AMALs, given how infrequently

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