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FIGURE 6  Change in medical students and Ukrainian trainees’   training disparities in DCR (Figure 7). Training disparities pose
              confidence.                                        a potential threat to patient safety and can result in potentially
                                                                 fatal acute hemolytic transfusion reactions. EFWBT program
                                                                 oversight requires a curriculum that encompasses training for
                                                                 all levels of medical practice, from physicians to advanced
                                                                 first responders, in both hospital and prehospital transport
                                                                       20
                                                                 settings.  Our training program addresses these disparities
                                                                 and makes meaningful contributions to increasing UHPs ca-
                                                                 pabilities by developing an EFWBT program that can be rep-
                                                                 licated at scale in resource-restrictive operating environments
                                                                 while drastically reducing preventable deaths, simultaneously
                                                                 increasing the safety and effectiveness of blood transfusions.

                                                                 FIGURE 7  The way forward for emergency fresh whole blood
                                                                 transfusion (EFWBT) training programs.





              ANOVA with an estimated marginal means post hoc analysis
              and Bonferroni correction, and the differences in scores be-
              tween the two population sets were analyzed using a Wilcoxon-
              Mann-Whitney U test.

              These  results  revealed  a statistically significant  p-value  of
              <.05 (α=0.05) (Appendix C). The pre- and post-training self-
              assessment median latencies of the UHPs and third-year med-
              ical  students  differed  significantly;  the  data  suggest  a  larger
              mean change in scores for the UHPs (p=.000065) (Figure 6).   A foundational step in implementing this program is the orga-
              The results of this study revealed that EFWBT training can   nization of a dedicated EFWBT team equipped with necessary
              significantly improve confidence in EFWBT for UHPs, setting   transfusion supplies and a keen understanding of transfusion
                                                                        21
              the foundation for continued research and development in im-  medicine.  Identifying and training  EFWBT instructors  and
              proving EFWBT training protocols on a global scale.  administrators, particularly medics and healthcare providers,
                                                                 are essential for delivering consistent, high-quality training
                                                                 and ensuring safe EFWBT practices in emergency situations.
              Discussion
                                                                 This team should adhere to strict guidelines for maintaining
              Our study provides a novel look at determining the value of   training requirements, donor testing, and tracking blood do-
              an EFWBT training program for UHPs and offers a founda-  nor/transfusion supply inventory to ensure the highest qual-
              tion to promulgate ongoing research and foster international   ity of medical training. The EFWBT program and curriculum
              collaboration. The Russia-Ukraine War has recently spurred   must cater to the specific requirements of the operating en-
              a wealth of research in capability assessments of Ukrainian   vironment, and strict administration oversight is crucial in
              medical systems, but there still remains a demand to resolve   ensuring the safety of both the donors and recipients.  The
              these multifaceted healthcare disparities.  Furthermore, there   EFWBT program should be designed to educate participants
                                             18
              is little to no research that offers a holistic understanding of   on proper transfusion procedures and safety protocols such
              the current capabilities of front-line UHPs proficiency in DCR.   as requisition of medical supplies, handling and storage of
              Continued research would not only increase our understanding   equipment, donor screening and data storage, indications for
              of disparities in Ukrainian medical training but also offer in-  EFWBT, preparation and inspection of donor/recipient trans-
              valuable insight for effectively managing EFWBT requirements   fusion equipment, identification of transfusion reactions and
              for U.S. Military assets in resource-limited, near-peer threat en-  treatments rendered, and concise guidelines on EFWBT.
              vironments. In order to garner a better understanding of these
              requirements, future U.S. Military collaboration with interna-  Additionally, UHPs in the hospital setting and involved in pre-
              tional partners and industry experts is paramount. Collabora-  hospital transport should maintain proficiency in EFWBT to
              tion in EFWBT will not only improve DCR capabilities but also   ensure a consistent supply of EFWB in the event of MCIs by
              aid in determining the unique logistical requirements that exist   developing protocols for screening, testing, and selecting po-
              when operating in resource-limited, near-peer threat environ-  tential blood donors to ensure donor suitability and safety.
                                                                                                               22
              ments, far-forward of traditional hospital care. Comparatively,   Collaboration with each tier of patient care, from point of in-
              there is limited accessibility to FWB and limited proficiency in   jury to long-term patient care, expands the resource pool and
              EFWBT training in Ukraine; this systematically contributes to   enhances the program’s ability to meet the demand for FWB
              the disparity in effectively treating patients on the battlefield. 19  in resource-restrictive environments. Implementing an EFWBT
                                                                 program on a larger scale requires careful planning, coordi-
              To resolve these limitations, our research team established a   nation, and adherence to regulatory guidelines to improve
              curriculum that assessed the confidence of UHPs in the appli-  emergency medical response, enhance survivability, and reduce
                                                                             23
              cation of managing an EFWBT program; this program serves   mortality rates.  Furthermore, periodic training in EFWBT at
              as a pilot for replicating EFWBT programs and resolving   every level of patient care refines medical skill sets, identifies
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