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hydration bladders could potentially be combined to grossly   traditional leather-upper offloading devices called “axial resist
          and hemodynamically stabilize larger extremity injuries.  orthoses,” functioning to unweight the ankle and calcaneus via
                                                             a rigid frame that bypasses the foot and ankle and connects
          Improvisation using vacuum splint techniques is limited due   to the shoe. 61,65  Device design was improved by replacing the
          to the nature of available materials and the need for a vacuum   leather component with more rigid thermoplastic components,
          apparatus. However, Air Force Pararescuemen carry a V-Vac   resulting in several commercially available devices (Figure
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          suction system in their primary medical kit.  This apparatus   5A). 52,53,55,61,66–72  These devices have an adjustable interface to
          may be utilized with available materials, such as a waterproof   simultaneously compensate for volumetric changes caused by
          bag, standard to many field medical personnel, filled with   swelling while applying compression to soft tissues and cir-
          soft materials (e.g., clothing/gauze). This mirrors the granular   cumventing the long bone fracture. Compression to the soft
          jamming demonstrated in conventional vacuum splints. These   tissues derives from principles associated with a patellar ten-
          examples underscore the potential for creating innovative im-  don-bearing prosthesis (PTB). The PTB was designed to apply
          provised splinting techniques using materials available to com-  loads  through  tissues  in  a transtibial  residual  limb  that  can
          bat or wilderness units in PCC scenarios and the extant need   tolerate loading (e.g., the tibialis anterior interosseous area be-
          to evaluate the effectiveness of these designs.    tween the tibia and fibula), while off-loading tissues that are
                                                             sensitive to pressure (e.g., crest of the tibia, proximal head of
                                                             the fibula). Current functional fracture orthotic interventions
          Orthotic Interventions
                                                             reportedly increase patient satisfaction and reduce pain during
          Functional fracture orthoses for definitive fracture man-  ambulation (Figure 5B). 61–64,73,74  Further, many of these design
          agement also highlight design features that could be used in   features have been incorporated into more modern treatments,
          splints developed for PCC scenarios (Figure 5). Functional   such as the Intrepid Dynamic Exoskeleton Orthosis, for indi-
          fracture orthoses accomplish stabilization by employing the   viduals that have undergone complex limb salvage operations
          principle of radial soft tissue compression around a long bone   and wish to return to high-level activities, including return to
          fracture. Further, these orthotic interventions incorporate ana-  duty (Figure 5C). 75,76
          tomic and mechanical support structures to off-load from the
          fracture site, enabling weight bearing and encouraging mobil-  The use of a functional femur fracture orthosis for compres-
          ity. Functional fracture orthoses have demonstrated success in   sion-based stabilization and off-loading of femur fractures
          traditional, definitive orthotic care scenarios due to the ability   presents challenges due to larger amounts of soft tissue sur-
          to adjust to volumetric fluctuations. This has resulted in faster   rounding the femur compared to that around the tibia. Yet,
          healing rates and decreased monetary expense compared to   designs developed for femoral fractures nevertheless rely on
          plaster casting, while being less medically invasive than surgi-  prosthetic off-loading design principles. By relying on the is-
          cal fixation. 52–55  Notably, fracture orthoses are not designed to   chial tuberosity of the pelvis in conjunction with a rigid struc-
          eliminate interfragmentary motion because successful fracture   ture running parallel to the intact leg and down to the ground,
          healing is dependent upon achieving a specific mechanical en-  ambulation has been achieved. The ischial tuberosity has been
          vironment, wherein an optimal amount of interfragmentary   used in both the Quadrilateral socket design from the 1950s
          motion is allowed at the fracture site and controlled by the   and the modern ischial containment socket prosthetic designs,
          stiffness of a stabilization device. 56,57  Proper control of inter-  intended for individuals with transfemoral amputation. 77,78  In-
          fragmentary motion allows for the sustained vascularization   corporating a proximal shelf that contacts the ischial tuberos-
          in the fracture callous that is required for successful ossifica-  ity of the pelvis reportedly off-loads the femoral shaft by 65%
          tion.  Fracture callous formation, critical to this fracture care   and reduces loads on the femoral neck by 30% during walk-
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          technique, is achieved via flexible fracture fixation or stabili-  ing, thus demonstrating the potential to utilize pelvic struc-
          zation that allows for 0.2–1.0-mm interfragmentary motion at   tures to off-load lower limb fractures in devices employed in
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          a fracture site displaced by 2-mm.  In contrast to small axial   austere environments. 79
          deformations, shear displacement at the fracture site has been
          shown to significantly delay facture healing, possibly leading   Fracture orthoses have several design features that are applica-
          to fracture non-union. 59,60  The use of fracture orthoses have   ble to the development of devices capable of being employed
          been primarily indicated in the management of low-energy   in a PCC scenario, particularly in the absence of surgical stabi-
          closed fractures of the tibia with >12-mm shortening and >5°   lization. The use of circumferential pressure applied along the
          angulation after  reduction.  Tibial fracture  orthosis contra-  limb segment through an adjustable interface may be sufficient
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          indications include presence of an intact fibula, polytrauma   to limit interfragmentary motion while allowing volumetric
          cases that prevent ambulation, or axially unstable fractures. 53,55    changes and access to wounded tissues. Utilizing the proximal
          While most battlefield injuries to the extremities involve pol-  tissues and a frame to bypass and off-load the injured tissues
          ytrauma, in which a traditional fracture orthosis will be con-  may provide opportunities for mobility after injury. The incor-
          traindicated, there are multiple design features in fracture   poration of energy storage and return components based on
          orthoses that have applicability for enhanced mobility in PCC   design features in the Intrepid Dynamic Exoskeleton. Orthosis
          scenarios. If fracture care treatments within PCC scenarios can   may also enhance this mobility.
          also incorporate the optimal ranges of interfragmentary mo-
          tion, then these PCC treatments may be complementary to de-  Biomaterial Approaches to
          finitive fracture treatment rendered after evacuation to higher   Local Fracture Stabilization
          echelons of care.
                                                             While providing external mechanical stabilization to fractures,
          The evolution of current functional fracture orthoses was de-  thereby enabling the injured person to bear weight, would
          veloped out of a blending of prosthetic and orthotic design   be a significant advancement in managing extremity injuries
          principles in the mid-1900s (Figure 5). These designs started as   within an austere environment, an opportunity also exists to

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