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HBOC-reconstituted cFDP, the investigators used equal vol- References
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necessarily reflect the physiology including the contribution of trauma sustained by civilian dogs and deployed military working
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study increasing the possibility of both type 1 and type 2 er- tion Iraqi Freedom: 29 cases (2003–2009). J Vet Emerg Crit Care.
rors. Nevertheless, the data presented here are encouraging for 2013;23(1):47–52.
the continued study of reconstitution of cFDP with HBOC for 9. Edwards TH, Rizzo JA, Pusateri AE. Hemorrhagic shock and he-
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Significant declines in coagulation parameters were seen at a 11. Joint Trauma System Clinical Practice Guideline on Transfusion
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Acknowledgments 14. Callan MB, Rentko VT. Clinical application of a hemoglo-
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Author Contributions 16. Driessen B, Jahr JS, Lurie F, et al. Effects of isovolemic resusci-
THE, MAM, GCP, and JAB conceived of the study concept tation with hemoglobin-based oxygen carrier Hemoglobin glu-
and design. THE and JAB obtained funding. THE, GCP, AFH, tamer-200 (bovine) on systemic and mesenteric perfusion and
RMH, and CSM collected and analyzed the data. THE, MAM, oxygenation in a canine model of hemorrhagic shock: a compari-
GCP, and JAB wrote the first draft. All authors read, edited, son with 6% hetastarch solution and shed blood. Vet Anaest An-
and approved the final manuscript. alg. 2006;33:368–380.
17. Liu DT, Silverstein DC. Crystalloids, colloids and hemoglobin
based oxygen-carrying solutions. In: Silverstein D, Hopper K,
Disclosures eds. Small Animal Critical Care Medicine. 2nd ed. St. Louis, MO:
The authors declare no conflicts of interest. Saunders; 2015.
18. Meledeo MA, Peltier GC, McIntosh CS, et al. Freeze-dried plasma
Disclaimer mitigates the dilution effects of a hemoglobin-based oxygen car-
The views expressed in this manuscript are those of the au- rier (HBOC-201) in a model of resuscitation for hemorrhage and
thors and do not reflect the official policy or position of the hemodilution. J Trauma Acute Care Surg. 2019;87:S83–S90.
Department of the Army, the Department of Defense, or the 19. Darlington DN, Craig T, Gonzales MD, et al. Acute coagulopa-
thy of trauma in the rat. Shock. 2013;39:440–446.
US Government.

Funding
This study was funded by a grant from the Department of
Defense Special Operations Command.

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