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patients: randomized controlled trial comparing ondansetron, 54. US Food and Drug Administration. FDA Drug Safety Com-
metoclopramide, and placebo. Ann Emerg Med. 2014;64:526– munication: new information regarding QT prolongation
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37. Patanwala A, Amini R, Hays D, et al. Antiemetic therapy for .gov/Drugs/DrugSafety/ucm310190.htm.
nausea and vomiting in the emergency department. J Emerg 55. Obal D, Yang D, Sessler D. Perioperative doses of ondanse-
Med. 2010;39:330–336. tron or dolasetron do not lengthen the QT interval. Mayo
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venous ondansetron for hyperemesis gravidarum. Am J Ob-
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39. Talesh K, Motamedi M, Kahnamouii S. Comparison of on-
dansetron and metoclopramide antiemetic prophylaxis in
maxillofacial surgery patients. Oral Surg Oral Med Oral LCDR Onifer is a family physician and undersea medical offi-
Pathol Oral Radiol Endod. 2011;111:275–277. cer currently serving with the Marine Special Operations Com-
40. Tang D, Malone D. A network meta-analysis on the efficacy mand. He has served as both a medical officer and a Special
of serotonin type 3 receptor antagonists used in adults dur- Amphibious Reconnaissance Corpsman with several US Marine
ing the first 24 hours for postoperative nausea and vomiting Corps reconnaissance units. E-mail: dana.j.onifer.mil@mail.mil.
prophylaxis. Clin Ther. 2012;34:282–294.
41. Metaxari M, Papaioannou A, Petrou A, et al. Antiemetic pro- CAPT (Ret) Butler was a Navy SEAL platoon commander
phylaxis in thyroid surgery: a randomized, double-blind com- before becoming a physician. He is an ophthalmologist with
parison of three 5-HT3 agents. J Anesth. 2011;25:356–362. more than 20 years’ experience providing medical support to
42. Chen Y, Yeh W, Lee K, et al. Intravenous ondansetron as Special Operations Forces. Dr Butler has served as the Com-
antiemetic prophylaxis for postoperative nausea and vomit- mand Surgeon for the US Special Operations Command and
ing after shoulder arthroscopy. Chang Gung Med J. 201;34: currently chairs the Department of Defense’s Committee on
205–212.
43. Tzeng J, Chu K, Ho S, et al. Prophylactic IV ondansetron re- TCCC.
duces nausea, vomiting and pruritus following epidural mor- COL Gross is a trauma surgeon with prior experience with
phine for postoperative pain control. Can J Anaesth. 2003;
50:1023–1026. the US Special Operations Command and combat-deployed
44. Jellish W, Leonetti J, Sawicki K, et al. Morphine/ondanse- forward surgical teams. He is currently the director of the
tron PCA for postoperative pain, nausea, and vomiting after Joint Trauma System and the Trauma Consultant to the Army
skull base surgery. Otolaryngol Head Neck Surg. 2006;135: Surgeon General.
175–181.
45. Fabi A, Ciccarese M, Metro G, et al. Oral ondansetron is CAPT (Ret) Otten is also a retired Army sergeant, who
highly active as rescue antiemetic treatment for moderately also served with the Marine Corps. He has more 35 years
emetogenic chemotherapy: results of a randomized phase II of Special Operations experience. Currently, he is professor of
study. Support Care Cancer. 2008;16:1375–1380. emergency medicine and pediatrics and director, Division of
46. Grover V, Mathew P, Hegde H. Efficacy of orally disinte- Toxicology, at the University of Cincinnati, Cincinnati, Ohio.
grating ondansetron in preventing postoperative nausea and
vomiting after laparoscopic cholecystectomy: a randomised, Dr Patton is an anesthesiologist in private practice in Pen-
double-blind placebo controlled study. Anaesthesia. 2009;64: sacola, Florida. He has served as past president of the medi-
595–600. cal staff of Gulf Breeze Hospital, past chief of anesthesia at
47. Hartsell T Long D, Kirsch J. The efficacy of postoperative Baptist Hospital, and past president of The Anesthesia Group.
ondansetron (Zofran) orally disintegrating tablets for pre-
venting nausea and vomiting after acoustic neuroma surgery. Dr Patton is currently director of anesthesia for the Gastro-
Anesth Analg. 2005;101:1492–1496. enterology Association of Pensacola.
48. Fullerton L, Weiss SJ, Froman P, et al. Ondansetron oral dis-
solving tablets are superior to normal saline alone for prehos- Col Russell, RAMC, is the senior lecturer in military emer-
pital nausea. Prehosp Emerg Care. 2012;16:463–468. gency medicine at the Academic Department of Military Emer-
49. VanDenBerg CM, Kazmi Y, Stewart J, et al. Pharmacokinet- gency Medicine, Royal Centre for Defence Medicine, and is a
ics of three formulations of ondansetron hydrochloride in consultant in emergency medicine at the Peterborough District
healthy volunteers: 24-mg oral tablet, rectal suppository, and Hospital.
I.V. infusion. Am J Health Syst Pharm. 2000;57:1046–1050.
50. Bozigian HP, Pritchard JF, Gooding AE, et al. Ondansetron CAPT Stockinger is a Navy trauma surgeon currently as-
absorption in adults: effect of dosage form, food, and ant- signed to the Joint Trauma System in San Antonio, Texas, as
acids. J Pharm Sci. 1994;83:1011–1013. the director for performance improvement. He has extensive
51. Singh N, Rai A, Selhorst J, et al. Ondansetron and seizures. operational medicine experience, including in East Timor, Haiti,
Epilepsia. 2009;50:2663–2666. Operation Iraqi Freedom, and Operation Enduring Freedom.
52. Kleinerman K, Deppe S, Sargent A. Use of ondansetron for
control of projectile vomiting in patients with neurosurgi- MSgt Burrell, USAF, is an aerospace medical service tech-
cal trauma: two case reports. Ann Pharmacother. 1993;27: nician assigned to the 66th Medical Squadron at Hanscom
566–568.
53. Hafermann MJ, Namdar R, Seibold GE, et al. Effect of intra- Air Force Base, Bedford, Massachusetts. She has 15 years of
venous ondansetron on QT interval prolongation in patients experience in family medicine, pediatrics, and education and
with cardiovascular disease and additional risk factors for training. She also served with the Joint Theater Trauma Sys-
torsades: a prospective, observational study. Drug Healthc tem in Afghanistan as the noncommissioned officer in charge
Patient Saf. 2011;3:53–58. and data analyst.

24 Journal of Special Operations Medicine Volume 15, Edition 2/Summer 2015