Page 33 - Journal of Special Operations Medicine - Summer 2015
P. 33
Operational Security Office at the US Army Institute of 17. Adam K, Oswald I. The hypnotic effects of an antihistamine:
Surgical Research. It is approved for unlimited public promethazine. Br J Clin Pharmacol. 1986;22:715–717.
release. 18. Behrbalk E, Halpern P, Boszczyk B, et al. Anxiolytic medica-
tion as an adjunct to morphine analgesia for acute low back
pain management in the emergency department: a prospective
Disclosures randomized trial. Spine. 2014;39:17–22.
19. Sheth H, Verrico M, Skledar S, et al. Promethazine adverse
The authors have no disclosures to report. events after implementation of a medication shortage inter-
change. Ann Pharmacother. 2005;39:255–261.
References 20. US Food and Drug Administration. FDA note to correspon-
dents: FDA requires boxed warning for promethazine hydro-
1. Braude D, Boling S. Case report of unrecognized akathisia chloride injection. 16 September 2009. http://www.fda.gov
resulting in an emergency landing and RSI during air medical /NewsEvents/Newsroom/PressAnnouncements/ucm182498
transport. Air Med J. 2006;25:85–87. .htm.
2. Barlow-Savko E, Forehand B, Carlson J. Antiemetic use in US 21. Chan-Tack KM. Neuroleptic malignant syndrome due to pro-
EDs. Am J Emerg Med. 2014;32:89–92. methazine. South Med J. 19;92:1017–1018.
3. Salvucci A, Squire B, Burdick M, et al. Ondansetron is safe 22. Cowings P, Toscano W, DeRoshia C, et al. Promethazine as a
and effective for prehospital treatment of nausea and vomit- motion sickness treatment: impact on human performance and
ing by paramedics. Prehosp Emerg Care. 2011;15:34–38. mood states. Aviat Space Environ Med. 2000;7:1013–1022.
4. Braude D, Crandall C. Ondansetron versus promethazine to 23. Hindmarch I, Shamsi Z, Stanley N, et al. A double-blind, pla-
treat acute undifferentiated nausea in the emergency depart- cebo-controlled investigation of the effects of fexofenadine,
ment: a randomized, double-blind, noninferiority trial. Acad loratadine and promethazine on cognitive and psychomotor
Emerg Med. 2008;15:209–215. function. Br J Clin Pharmacol. 1999;48:200–206.
5. Easton R, Bendinelli C, Sisak K, et al. Prehospital nausea and 24. Kamei H, Isaji A, Noda Y, et al. Effects of single therapeutic
vomiting after trauma: prevalence, risk factors, and develop- doses of promethazine, fexofenadine and olopatadine on psy-
ment of a predictive scoring system. J Trauma Acute Care chomotor function and histamine-induced wheal- and flare-
Surg. 2012;72:1249–1253. responses: a randomized double-blind, placebo-controlled study
6. Phenergan (promethazine hydrochloride) injection, solution. in healthy volunteers. Arch Dermatol Res. 2012;304:263–272.
November 2009. http://dailymed.nlm.nih.gov/dailymed/lookup 25. Kavanagh J, Grant G, Anoopkumar-Dukie S. Low dosage
.cfm?setid=64972f75-d329-4897-941b-ad7fd71c6804#nlm promethazine and loratadine negatively affect neuromotor
34090-1. function. Clin Neurophysiol. 2012;123:780–786.
7. Phenergan (promethazine) drug information: clinical pharma- 26. Naicker P, Anoopkumar-Dukie S, Grant G, et al. The effects of
cology—prescribing information at RxList. 21 June 2007. antihistamines with varying anticholinergic properties on vol-
http://www.rxlist.com/phenergan-drug/clinical-pharmacology untary and involuntary movement. Clin Neurophysiol. 2013;
.htm. 124:1840–1845.
8. Owczuk R, Twardowski P, Dylczyk-Sommer A, et al. Influence 27. Ridout F, Hindmarch I. The effects of acute doses of fexof-
of promethazine on cardiac repolarisation: a double-blind, enadine, promethazine, and placebo on cognitive and psycho-
midazolam-controlled study. Anaesthesia. 2009;64:609–614. motor function in healthy Japanese volunteers. Ann Allergy
9. Zofran (ondansetron hydrochloride) drug information: clini- Asthma Immunol. 2003;90:404–410.
cal pharmacology—prescribing information at RxList. 26 28. Ernst A, Weiss S, Park S, et al. Prochlorperazine versus pro-
September 2011. http://www.rxlist.com/zofran-drug/clinical- methazine for uncomplicated nausea and vomiting in the
pharmacology.htm. emergency department: a randomized, double-blind clinical
10. Freedman SB, Uleryk E, Rumantir M, et al. Ondansetron and trial. Ann Emerg Med. 2000;36:89–94.
the risk of cardiac arrhythmias: a systematic review and post- 29. Vella L, Francis D, Houlton P, et al. Comparison of the anti-
marketing analysis. Ann Emerg Med. 2014;64:19–25. emetics metoclopramide and promethazine in labour. Br Med
11. Reglan (metoclopramide) drug information: clinical phar- J (Clin Res Ed). 1985;290:1173–1175.
macology—prescribing information at RxList. 17 December 30. Foret A, Bozeman A, Floyd W. Necrosis caused by intra-
2010. http://www.rxlist.com/reglan-drug.htm. arterial injection of promethazine: case report. J Hand Surg
12. Inapsine (droperidol) drug information: clinical pharmacol- Am. 2009;34:919–923.
ogy—prescribing information at RxList. 5 June 2008. http:// 31. Keene J, Buckley K, Small S, et al. Accidental intra-arterial in-
www.rxlist.com/inapsine-drug.htm. jection: a case report, new treatment modalities, and a review
13. Barrett T, DiPersio D, Jenkins C, et al. A randomized, pla- of the literature. J Oral Maxillofac Surg. 2006;64:965–968.
cebo-controlled trial of ondansetron, metoclopramide, and 32. Paula R, Peckler B, Nguyen M, et al. Catastrophic complica-
promethazine in adults. Am J Emerg Med. 2011;29:247–255. tions of intravenous promethazine. Am J Emerg Med. 2010;
14. Chia Y, Lo Y, Liu K, et al. The effect of promethazine on 28:535.e1–e4.
postoperative pain: a comparison of preoperative, postopera- 33. Patka J, Wu D, Abraham P, Sobel R. Randomized controlled
tive, and placebo administration in patients following total trial of ondansetron vs. prochlorperazine in adults in the
abdominal hysterectomy. Acta Anaesthesiol Scand. 2004;48: emergency department. West J Emerg Med. 2011;12:1–5.
625–630. 34. Domino K, Anderson E, Polissar N, et al. Comparative ef-
15. Habib A, Reuveni J, Taguchi A, et al. A comparison of on- ficacy and safety of ondansetron, droperidol, and metoclo-
dansetron with promethazine for treating postoperative nau- pramide for preventing postoperative nausea and vomiting: a
sea and vomiting in patients who received prophylaxis with meta-analysis. Anesth Analg. 1999;88:1370–1379.
ondansetron: a retrospective database analysis. Anesth Analg. 35. Cox F. Systematic review of ondansetron for the preven-
2007;104:548–551. tion and treatment of postoperative nausea and vomiting in
16. Moser J, Caldwell J, Rhule F. No more than necessary: safety adults. Br J Theatre Nurs. 1999;9:556–563, 566.
and efficacy of low-dose promethazine. Ann Pharmacother. 36. Egerton-Warburton D, Meek R, Mee M, et al. Antiemetic
2006;40:45–48. use for nausea and vomiting in adult emergency department
Replacement of Antiemetics in TCCC 23

