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an improved risk­to­benefit ratio for tourniquet use dur­  overtightening the first tourniquet to stop both bleed­
          ing the 21st century wars.                         ing and the distal pulse. 35

          Potential complications of tourniquet use are many,   Clinical evidence indicates that field tourniquet place­
          and have been reported in great detail in the orthopedic   ment may be effective, but at the hospital or after resus­
          surgery literature. 40,41  However, the complications from   citation is begun, the tourniquet may become ineffective
          emergency tourniquet use are much more difficult to   due to an increase in the blood pressure ; this loss of
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          quantify in comparison to elective surgery, due to the ef­  effectiveness during resuscitation underscores the need
          fects of the injury itself, which may contribute to similar   for reassessment of tourniquet use so that the tourni­
          outcomes. Kragh et al. selected the following complica­  quet may be retightened or adjusted. New evidence also
          tions to report in their prospective observational study   indicates that initial tourniquet placement may be effec­
          of tourniquet use: amputation, fasciotomy, clot, palsy,   tive, but within a minute muscle tension under the tour­
          myonecrosis, acute renal failure, significant pain, and   niquet may lessen and cause the tourniquet to become
          rigor. 1,19  In general, complications of tourniquet use re­  ineffective ; this early loss of effectiveness underscores
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          sult from direct pressure at the site of the tourniquet,   the need for early reassessment of tourniquet use so that
          venous congestion, rebleeding from a partially occlusive   the tourniquet may be retightened or adjusted.
          tourniquet, or ischemia induced by arterial occlusion.
                                                             Training must emphasize that tourniquets need to stop
          Direct pressure injuries are risked with narrower tourni­  both bleeding and the distal pulse and that frequent re­
          quets and higher tourniquet pressures, resulting in nerve   assessment is essential to maintain effectiveness of the
          palsy, vascular injury, or direct tissue injury. Such iat­  tourniquet. It is recognized that partial amputation and
          rogenic injuries may be minimized through the use of   isolated arterial injury may result in no palpable distal
          wider tourniquets at lower compression pressures. 42,43    pulse. In many combat situations, obtaining full expo­
          Device selection has been instrumental in reducing   sure and removing footwear to check pulses may be de­
          direct­ pressure injuries. TCCC guidelines and training   layed; in such cases, visibly confirming control of wound
          have also recommended placement of a second tourni­  hemorrhage suffices. In darkness, palpation for pulses
          quet side by side with the first if the initial application is   may be more useful than observing for hemorrhage.
          ineffective, thereby effectively widening the tourniquet,
          an innovation from users in the field that led Dr. John   Ischemic complications increase as tourniquet time in­
          Kragh to clarify its usefulness and to propose its imple­  creases. There is no consensus on an absolutely safe du­
          mentation  formally.   Conversion to  wider  pneumatic   ration for tourniquet use; however, a range of 1–3 hours
                           35
          tourniquets, as is frequently done on arrival to a surgical   has been suggested, with 2 hours accepted as a useful
          facility, may further reduce the risk of pressure injuries.   guideline for safe use during elective surgery. 1,45–49  Serum
                                                             creatine phosphokinase (CPK) level has been used as a
          The “venous tourniquet” occurs when the tourniquet   marker for limb muscle damage at and distal to the tour­
          is  tight enough to occlude venous outflow from the   niquet. In dogs, the CPK level does not increase after
          limb while failing to occlude arterial inflow. Continued   1 hour of ischemia, but does rise after 2–3 hours of isch­
          inflow of blood with impaired outflow leads to loss   emia.  In addition, Olivecrona et al. demonstrated that
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          of blood in the body’s core and swelling of the distal   tourniquet times longer than 100 minutes were associ­
          limb with higher risk of compartment syndrome, but   ated with an increase in complications after knee arthro­
          may also increase the amount of wound bleeding, par­  plasty (independent of comorbidities or primary/revision
          ticularly from venous injuries. Kragh et al.,  in 2008,   indication), with the odds of a complication increasing
                                                 1
          reported that 44 of 232 casualties with prehospital­   by 20% for each 10 minutes of longer tourniquet time
          applied tourniquets had persistent bleeding on arrival   throughout a range of 39–156 minutes.  Other authors
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          to a CSH and 43 of the 232 had persistent distal pulses;   have postulated that the effects of traumatic injury and
          these casualties experienced an increased morbidity   blood loss may reduce the ischemic tolerance of the limb
          and mortality rate. The authors described the clinical   in comparison to elective surgery, suggesting that safe
          progression associated  with  ineffective tourniquets:   tourniquet times may be shorter than expected for pa­
          persistent pulse, venous congestion, venous distension,    tients in shock. 52,53
          rebleeding  after  a  period  of  hemorrhage  control,  ex­
          panding hematomas, compartment syndrome, fasci­    In general, minimizing tourniquet time is the most effec­
          otomy, and death. 1,19  These observations resulted in   tive strategy to minimize the risks of tourniquet­related
          two refinements of the TCCC guidelines in 2008: (1)   injury. Minimizing harm is particularly important for
          the elimination of the distal pulse on the extremity was   those casualties who may have had a tourniquet placed
          added as a goal of tourniquet application, and (2) the   for hemorrhage that is not life threatening, which may
          recommendation to use a second tourniquet rather than   frequently occur in real­world scenarios during CUF.



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