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www.tacmedsolutions.com/), and the Emergency &     The Israeli Defense Force experience was reported in a
          Military Tourniquet  (Delfi Medical Innovations Inc.;   retrospective study of 550 casualties, 91 of whom re­
          http://www.delfimedical.com/) were all effective at stop­  ceived a tourniquet. They reported no deaths from un­
                                               14
          ping distal blood flow in human volunteers.  The C­A­T    controlled limb hemorrhage and a 47% incidence of
          has since become the most widely fielded tourniquet in   nonindicated tourniquet placement, based on both tacti­
                                             28
          the US military, initially by USSOCOM and later by   cal and anatomic indications taught in training; 78% of
          the rest of the US military. By 2006, after a decade of   tourniquets were effective (completely stopped bleeding)
          commitment by key advocates to design, test, train,   and neurologic complications occurred in 6.4% of limbs
          and field battlefield tourniquets, tourniquet use on the   with tourniquet times of 109 to 187 minutes. 31
          battlefield had become ubiquitous. 7,17  In 2009, Kragh et
          al. demonstrated clearly that for casualties with uncon­  A retrospective review of all 165 patients arriving at
          trolled limb hemorrhage, survival with tourniquet use   Baghdad’s  31st  Combat  Support  Hospital  (CSH)  in
          was  higher  than  without,  particularly  if  a  tourniquet   2004 with major traumatic amputation, extremity vas­
          was applied before onset of shock, emphasizing that,   cular injury, or prehospital tourniquet compared casu­
          within the comprehensive military trauma system, with   alties with tourniquets applied prehospital and in the
          effective devices, along with training and fielding to all   emergency department (40% of casualties) to those
          forces,  mortality  was  improved  while  morbidity  was   without  tourniquet  use  (60%).  Tourniquet  use  was
          minimized. 9                                       associated  with  improved  hemorrhage  control  in this
                                                             study. Of note, 18% of tourniquets were nonindicated,
          Preventable Deaths                                 15% were ineffective, and rebleeding occurred in an­
          Analysis of combat mortality data during the Iraq and   other 15% after resuscitation. No tourniquet­related
          Afghanistan wars led to an improved understanding of   complications were reported. This study, conducted at
          the potentially preventable causes of combat death and   a time before widespread tourniquet training and dis­
          spurred new strategies for medical treatment, training,   tribution to US forces, demonstrated that four of seven
          and equipment. A focus on limb hemorrhage, in par­  deaths might have been prevented with earlier tourni­
          ticular, provided the data to support widespread imple­  quet use. 32
          mentation of tourniquet use by US forces. An analysis
          of 82 fatalities in US SOF from 2001 to 2004 showed   In 2006–2007, a prospective observational survey (in
          12 deaths (15%) resulted from potentially survivable   three time periods) was conducted at a single CSH in
          wounds, including three of 12 (25%) with “tourniqu­  Iraq. These reports demonstrated 90% mortality for ca­
                            15
          etable” hemorrhage.  A larger study published in 2008   sualties with tourniquets placed after the onset of shock
          of 982 US military fatalities showed similar results, with   and 10% mortality for those with tourniquets placed
          24%  of  deaths  designated  potentially  survivable  and   before shock onset, providing strong support for early
          33% of the potentially preventable deaths attributed to   tourniquet use. Ineffective tourniquet placement (per­
          limb hemorrhage. 29                                sistent bleeding or persistent distal pulses) occurred in
                                                             28% of patients. Morbidity in this series was low, with
          In 2012, Eastridge et al. published an analysis of 4,596   a 1.7% incidence of transient nerve palsy and no ampu­
                                                    30
          battlefield deaths occurring from 2001 to 2011.  This   tation directly attributable to tourniquet use alone, al­
          largest study reinforced the findings of prior studies, with   though an increase in both amputation and fasciotomy
          24% of prehospital combat deaths designated as poten­  rates was associated with tourniquet use longer than
          tially survivable.  Of  the potentially  survivable  deaths,   2 hours. Morbidity assessment was challenging with
          91% resulted from hemorrhage, with 12% attributed   many associated injuries, and long­term follow­up was
          specifically to limb hemorrhage. This study also focused   absent in these reports. However, the lifesaving benefit
          renewed  attention  on  prehospital  interventions,  since   of early tourniquet use was clearly demonstrated. 1,9,10,33
          87% of combat deaths occurred before arrival at a medi­
          cal treatment facility. A clear decrease in deaths from   The 75th Ranger Regiment experience was reported
          limb hemorrhage over the course of the war was dem­  in a retrospective study of 419 casualties; a total of 89
          onstrated, with a 6.7­fold decrease in limb­hemorrhage   limb tourniquets were applied to 66 casualties with no
          deaths occurring after full implementation of training   resultant complications. Of these casualties with tourni­
          and dissemination of tourniquets among US forces.  quets, 95% reached the next level of care alive and 94%
                                                             ultimately survived. Sixteen percent of these survivors
          Published Series on Tourniquet Use                 had underlying injuries that resulted in limb amputa­
          Battlefield tourniquet use in the modern era has demon­  tions; however, no amputation was attributed directly
          strated a positive risk­to­benefit ratio, saving lives with   to tourniquet use. Additionally, this study noted that
          low incidence of morbidity. Several series of combat use   nonmedical personnel performed 42% of tourniquet
          have been reported.                                applications. 34



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