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model developed by the USAISR. Dressings with 5. Mueller GR, Pineda TJ, Xie HX, et al. A novel sponge-
strong efficacy in the screening studies currently based wound stasis dressing to treat lethal noncompressible
being conducted by USAISR should undergo full hemorrhage. J Trauma Acute Care Surg. 2012;73:S134–
efficacy and safety studies in both a normal and co- S139.
agulopathic animal models. 6. Rall JM, Cox JM, Songer AG, et al. Comparison of novel
4. Hemostatic dressings should be evaluated for ef- hemostatic gauzes to QuikClot Combat Gauze in a stan-
dardized swine model of uncontrolled hemorrhage. J
ficacy beyond the 3-hour duration used in current Trauma Acute Care Surg. 2013;75(2 Suppl 2):S150–S156.
animal studies out to 12 to 72 hours based in new 7. Kunio N, Riha GM, Watson KM, et al. Chitosan based
worldwide operational contingencies in austere en- hemostatic dressing is associated with decreased blood
vironments resulting in prolonged pre-hospital care loss in a swine uncontrolled hemorrhage model. Am J
and delayed medical evacuation. Surg. 2013;205:505–510.
8. Satterly S, Nelson D, Zwintscher N, et al. Hemostasis in a
Disclaimers noncompressible hemorrhage model: An end-user evalu-
ation of hemostatic agents in a proximal arterial injury. J
The opinions or assertions contained herein are the pri- Surg Educ. 2013;70:206–211.
vate views of the authors and are not to be construed as 9. Kheirabadi BS, Mace JE, Terrazas IB, et al. Clot inducing
official or as reflecting the views of the Department of minerals versus plasma protein dressing for topical treat-
the Navy, the Department of the Army, or the Depart- ment of external bleeding in the presence of coagulopa-
ment of Defense. The recommendation contained herein thy. J Trauma. 2010;69:1062–1073.
is the current position of the Department of Defense 10. Floyd CT, Rothwell SW, Risdahl J, et al. Salmon throm-
Joint Trauma System CoTCCC. This recommendation bin-fibrinogen dressing allows greater survival and pre-
serves distal blood flow compared to standard kaolin
is intended to be a guideline only and is not a substitute gauze in coagulopathic swine with a standardized lethal
for clinical judgment. femoral artery injury. J Spec Oper Med. 2012;12:16–26.
11. King DR. Thirty consecutive uses of a hemostatic bandage
Disclosures at a US Army Combat Support Hospital and Forward
Surgical Team in Operation Iraqi Freedom. J Trauma.
The authors have no financial disclosures or anything 2011;71:1775–1778.
else to disclose. 12. Causey MW, McVay DP, Miller S, et al. The efficacy of
Combat Gauze in extreme physiologic conditions. J Surg
Release Res. 2012;177:301–305.
13. Sena MJ, Douglas G, Gerlach T, et al. A pilot study of
This document was reviewed by the Director of the the use of kaolin-impregnated gauze (Combat Gauze) for
Joint Trauma System, the Public Affairs Office, and the packing high-grade hepatic injuries in a hypothermic co-
Operational Security Office of the US Army Institute of agulopathic swine model. J Surg Res. 2013;183:704–709.
Surgical Research and approved for unlimited public re- 14. Kheirabadi BS. Evaluation of topical hemostatic agents
lease as of 22 April 2014. for combat wound treatment. US Army Med Dept J.
2011;2:25–37.
15. Granville-Chapman J, Jacobs N, Midwinter MJ. Pre-
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Chitosan-Based Hemostatic Gauze Dressings 55

